UPLC-MS/MS法测定火锅底料中三种喹噁啉类药物

doi:10.14088/j.cnki.issn0439-8114.2020.03.027

湖北农业科学 ›› 2020, Vol. 59 ›› Issue (3): 126-129.doi: 10.14088/j.cnki.issn0439-8114.2020.03.027

UPLC-MS/MS法测定火锅底料中三种喹噁啉类药物

马晓年¹, 段海波², 邹艳丽³, 张秀清¹, 梁志坚¹, 陈俊秀¹

1.昆明市疾病预防控制中心,昆明 650228;
2.云南中烟工业有限责任公司技术中心,昆明 650231;
3.楚雄师范学院,云南楚雄 675000

收稿日期:2019-06-10 发布日期:2020-05-11
通讯作者: 陈俊秀（1988-）,女,云南玉溪人,初级检验师,主要从事理化分析工作,（电子信箱）752110643@qq.com。
作者简介:马晓年（1985-）,女（壮族）,云南临沧人,主管技师,硕士,主要从事食品质量与安全工作,（电话）13888021164（电子信箱） 179267837@qq.com。
基金资助:
昆明市卫生人才科技人才培养项目[2017-sw（后备）-66]

Determination of 3 quinoxaline drugs in hotpot seasoning by UPLC-MS/MS

MA Xiao-nian¹, DUAN Hai-bo², ZOU Yan-li³, ZHANG Xiu-qing¹, LIANG Zhi-jian¹, CHEN Jun-xiu¹

1.Kunming Center for Disease Control and Prevention,Kunming 650228,China;
2.Yunnan Tobacco Industry Co.,Ltd. Technology Center,Kunming 650231,China;
3.Chuxiong Normal University,Chuxiong 675000,Yunnan,China

Received:2019-06-10 Published:2020-05-11

摘要/Abstract

摘要： 采用超高效液相色谱-串联三重四级杆质谱同时检测火锅底料中3种喹噁啉药物,样品经过乙腈-乙酸乙酯提取后,以乙腈-0.2%甲酸作为流动相,采用多反应检测正离子模式进行定性及定量分析。结果表明,3种喹噁啉类药物的线性关系良好,相关系数均在0.999以上,不同浓度的平均加标回收率在66.5%~84.4%,平均相对标准偏差为6.8%~9.2%,该方法适用于火锅底料中3种喹噁啉类药物残留的检测。

关键词: 3-甲基喹噁啉-2-羧酸, 乙酰甲喹, 喹烯酮, UPLC-MS/MS, 火锅底料

Abstract: UPLC-MS/MS was used to simultaneously detect three quinoxaline drugs in the hotpot seasoning. After the sample was extracted by acetonitrile ethyl acetate, acetonitrile-0.2% formic acid water was used as the mobile phase, and the multi reaction detection positive ion mode was used for qualitative and quantitative analysis. The results show that the linear relationship of the three quinoxaline drugs is good, the correlation coefficient is above 0.999, the average recovery of different concentration is 66.5%~84.4%, and the average relative standard deviation is 6.8%~9.2%. This method is suitable for the detection of residual pollution in hotpot seasoning.

Key words: methyl-3-quinoxaline-2-carboxylic acid, mequindox, quinocetone, UPLC-MS/MS, hotpot seasoning

中图分类号:

马晓年, 段海波, 邹艳丽, 张秀清, 梁志坚, 陈俊秀. UPLC-MS/MS法测定火锅底料中三种喹噁啉类药物[J]. 湖北农业科学, 2020, 59(3): 126-129.

MA Xiao-nian, DUAN Hai-bo, ZOU Yan-li, ZHANG Xiu-qing, LIANG Zhi-jian, CHEN Jun-xiu. Determination of 3 quinoxaline drugs in hotpot seasoning by UPLC-MS/MS[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(3): 126-129.

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UPLC-MS/MS法测定火锅底料中三种喹噁啉类药物

Determination of 3 quinoxaline drugs in hotpot seasoning by UPLC-MS/MS

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