钙调素结合位点调控环核苷酸门控离子通道研究进展

doi:10.14088/j.cnki.issn0439-8114.2021.20.001

湖北农业科学 ›› 2021, Vol. 60 ›› Issue (20): 5-9.doi: 10.14088/j.cnki.issn0439-8114.2021.20.001

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钙调素结合位点调控环核苷酸门控离子通道研究进展

余冰清, 严汉池

天津大学生命科学学院,天津 300072

收稿日期:2020-08-02 出版日期:2021-10-25 发布日期:2021-11-05
通讯作者: 严汉池,男,江苏淮安人,研究员,博士,主要从事结构生物学研究,（电子信箱）hanchiyan@126.com。
作者简介:余冰清（1996-）,女,江苏仪征人,在读硕士研究生,研究方向为结构生物学,（电话）18722029366（电子信箱）bingqingyu961008@163.com。

Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels

YU Bing-qing, YAN Han-chi

School of Life Sciences,Tianjin University,Tianjin 300072,China

Received:2020-08-02 Online:2021-10-25 Published:2021-11-05

摘要/Abstract

摘要： 环核苷酸门控离子通道（Cyclic nucleotide-gated ion channels,CNGC）是非选择性的阳离子通道,受细胞内信使小分子环核苷酸（cAMP和cGMP）以及Ca²⁺/CaM调控。哺乳动物CNGC功能的变构调节机制受到CaM结合影响,哺乳动物CNGC在胞质N和/或C末端具有CaMBD。在植物方面,研究大多集中于与植物CNGC的环核苷酸结合结构域重叠的C端CaM结合结构域（CaMBD）。然而近期对模式植物拟南芥CNGC12的研究提供了单个植物CNGC同种型具有多个CaMBD的证据。重点总结了动植物钙调蛋白多个结合位点调控环核苷酸门控离子通道的研究进展。

关键词: 环核苷酸门控离子通道（CNGC）, 钙调素CaM, 环化核苷酸（cNMP）

Abstract: Cyclic nucleotide-gated ion channels （CNGC） are non-selective cation channels, regulated by intracellular messenger small molecule cyclic nucleotides （cAMP and cGMP） and Ca²⁺/CaM. The allosteric regulation mechanism of mammalian CNGC function is affected by the binding of CaM, and mammalian CNGC has CaMBD at the cytoplasmic N and/or C-terminus. In plants side,most of the research has focused on the C-terminal CaM binding domain （CaMBD） that overlaps with the cyclic nucleotide binding domains of plant CNGC. However, recent studies on the model plant Arabidopsis CNGC12 has provided evidence that a single plant CNGC isoform has multiple CaMBDs. This review focuses on the research progress in the regulation of calmodulin binding sites in plant and animal cyclic nucleotide-gated ion channels.

Key words: cyclic nucleotide-gated ion channels, calmodulin, cyclic nucleotide

中图分类号:

Q342

余冰清, 严汉池. 钙调素结合位点调控环核苷酸门控离子通道研究进展[J]. 湖北农业科学, 2021, 60(20): 5-9.

YU Bing-qing, YAN Han-chi. Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(20): 5-9.

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钙调素结合位点调控环核苷酸门控离子通道研究进展

Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels

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