泛素化修饰在DNA损伤修复中的功能研究进展

doi:10.14088/j.cnki.issn0439-8114.2020.24.003

湖北农业科学 ›› 2020, Vol. 59 ›› Issue (24): 16-20.doi: 10.14088/j.cnki.issn0439-8114.2020.24.003

泛素化修饰在DNA损伤修复中的功能研究进展

秦小兵

武汉大学医学研究院,武汉 430061

收稿日期:2020-07-20 出版日期:2020-12-25 发布日期:2021-01-21
作者简介:秦小兵(1992-),男,贵州仁怀人,硕士,主要从事DNA损伤修复研究,(电话)18586527881(电子信箱)2017206500018@whu.edu.cn

Research progress on the function of ubiquitination modification in DNA damage repair

QIN Xiao-bing

Medical Research Institue, Wuhan University, Wuhan 430061, China

Received:2020-07-20 Online:2020-12-25 Published:2021-01-21

摘要/Abstract

摘要： DNA损伤会导致基因组不稳定,从而导致正常细胞发生癌变。DNA损伤修复过程对于细胞维持基因组稳定性,防止细胞癌变有重要意义。细胞内有许多DNA损伤修复因子参与DNA损伤修复,而许多修复因子在行使修复功能时会发生翻译后修饰,其中泛素化修饰是重要的修饰方式之一。重点介绍泛素化修饰在各种DNA损伤修复途径中的研究进展,从而为相关疾病的治疗和基础研究提供相应的理论依据。

关键词: DNA损伤, DNA损伤修复, 基因突变, 癌变, 泛素化修饰

Abstract: DNA damage can cause instability of genome, therefore, which makes the normal cells cancerous. Therefore, the DNA damage repair is essential for genome stability and preventing cells from becoming cancerous. There are numerous DNA damage repair factors participate in DNA damage repair response in the cells, some of them will be modificated when they functionating in DNA damage repair response, one of the most significant modifications is ubiquitination modification. In this review, we will shed light on the research progress of ubiquitination modification in the DNA damage repair response,and to provide theoretical basis for the treatment and basic research of related diseases correspondingly.

Key words: DNA damage, DNA damage repair, mutations, canceration, ubiquitination

中图分类号:

秦小兵. 泛素化修饰在DNA损伤修复中的功能研究进展[J]. 湖北农业科学, 2020, 59(24): 16-20.

QIN Xiao-bing. Research progress on the function of ubiquitination modification in DNA damage repair[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(24): 16-20.

参考文献

[1] JACKSON S P, DUROCHER D.Regulation of DNA damage responses by ubiquitin and SUMO[J]. Molecular cell, 2013, 49(5):795-807.
[2] GARNER E, SMOGORZEWSKA A.Ubiquitylation and the Fanconi anemia pathway[J]. Febs letters, 2011, 585(18):2853-2860.
[3] BRINKMANN K, SCHELL M, HOPPE T, ET A L.Regulation of the DNA damage response by ubiquitin conjugation[J]. Frontiers in genetics, 2015, 6:98.
[4] CIECHANOVER A, FINLEY D, VARSHAVSKY A.Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85[J]. Cell, 1984, 37(1):57-66.
[5] SCHEFFNER M, NUBER U, HUIBREGTSE J M.Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade[J]. Nature (London), 1995, 373(6509):81-83.
[6] HERSHKO A,CIECHANOVER A.The ubiquitin system[J]. Annual review of biochemistry,1998, 67(1):425-479.
[7] PAUL A,WANG B.RNF8- and Ube2S-dependent ubiquitin lysine 11-linkage modification in response to DNA damage[J]. Molecular cell, 2017, 66(4):458-472.
[8] JENTSCH S, MCGRATH J P, VARSHAVSKY A.The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme[J]. Nature, 1987, 329(6135):131-134.
[9] LEHMANN A R.Ubiquitin-family modifications in the replication of DNA damage[J]. Febs letters, 2011, 585(18):2772-2779.
[10] HOEGE C,PFANDER B,MOLDOVAN G L,et al.Rad6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO[J]. Nature (London), 2002, 419(6903):135-141.
[11] KNIPSCHEER P,RASCHLE M,SMOGORZEWSKA A,et al.The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair[J]. Science,2009,326(5960):1698-1701.
[12] JOO W,XU G,PERSKY N S,et al.Structure of the FANCI-FANCD2 complex: Insights into the Fanconi anemia DNA repair pathway[J]. Science, 2011, 333(6040):312-316.
[13] TANIGUCHI T,GARCIA-HIGUERA I,ANDREASSEN P R,et al.S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51[J]. Blood,2002,100(7):2414-2420.
[14] WANG X Z, ANDREASSEN P R, D'ANDREA A D. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin[J]. Molecular & cellular biology,2004,24(13):5850-5862.
[15] PETROSKI M D,DESHAIES R J.Function and regulation of cullin-RING ubiquitin ligases[J]. Nat rev mol cell biol, 2005, 6(1):9-20.
[16] SCRIMA A, FISCHER E S, LINGARAJU G M, et al.Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best[J]. Febs letters, 2011, 585(18):2818-2825.
[17] SUGASAWA K, OKUDA Y, SAIJO M, et al.UV-Induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex[J]. Cell, 2005, 121(3):387-400.
[18] SUGASAWA K.UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair[J]. Journal of molecular histology, 2006, 37(5-7):189-202.
[19] HÉLÈNE G, ANDRÉS A. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis[J]. Biochimica et biophysica acta (bba), 2013, 1829(1):141-150.
[20] EPANCHINTSEV A,COSTANZO F,RAUSCHENDORF M A,et al.Cockayne's syndrome A and B proteins regulate transcription arrest after genotoxic stress by promoting ATF3 degradation[J]. Molecular cell, 2017,68(6):1054-1066.
[21] WILSON M D,HARREMAN M,SVEJSTRUP J Q.Ubiquitylation and degradation of elongating RNA polymerase II: The last resort[J]. Biochimica et biophysica acta (bba)-gene regulatory mechanisms, 2013, 1829(1):151-157.
[22] STUCKI M, CLAPPERTON J A, MOHAMMAD D, et al.MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks[J]. Cell, 2008, 123(7):1213-1226.
[23] HUEN M S Y, GRANT R, MANKE I, et al. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly[J]. Cell, 2007, 131(5):901-914.
[24] LUKAS J, LUKAS C, BARTEK J.More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance[J]. Nature cell biology,2011,13(10):1161-1169.
[25] ZHU B, ZHENG Y, PHAM A D, et al.Monoubiquitination of human histone H2B: The factors involved and their roles in HOX gene regulation[J]. Molecular cell, 2005, 20(4):601-611.
[26] NAKAMURA K, KATO A, KOBAYASHI J, et al.Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.[J]. Molecular cell, 2011, 41(5):515-528.
[27] MOYAL L,LERENTHAL Y,GANAWEISZ M,et al.Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks[J]. Molecular cell,2011, 41(5):529-542.
[28] LEE B L, SINGH A, GLOVER J N M, et al. Molecular basis for K63-linked ubiquitination processes in double-strand DNA break repair: A focus on kinetics and dynamics[J]. Journal of molecular biology,2017,429(22):3409-3429.
[29] AL-HAKIM A, IEMURA S I, JUANG Y C, et al.Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1[J]. Nature, 2010, 466(7309):941-946.
[30] GIENI R S, ISMAIL I H, CAMPBELL S, et al.Polycomb group proteins in the DNA damage response: A link between radiation resistance and “stemness”[J]. Cell cycle, 2011, 10(6):883-894.
[31] DENSHAM R M, GARVIN A J, STONE H R, et al.Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection[J]. Nature structural & molecular biology,2016,23:647-655.
[32] BARANES-BACHAR K,LEVY-BARDA A,OEHLER J,et al.The ubiquitin E3/E4 Ligase UBE4A adjusts protein ubiquitylation and accumulation at sites of DNA damage, facilitating double-strand break repair[J]. Molecular cell, 2018, 69(5):866-878.

泛素化修饰在DNA损伤修复中的功能研究进展

Research progress on the function of ubiquitination modification in DNA damage repair

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