弧菌噬菌体裂解酶和解聚酶的研究进展

doi:10.14088/j.cnki.issn0439-8114.2025.08.028

湖北农业科学 ›› 2025, Vol. 64 ›› Issue (8): 183-188.doi: 10.14088/j.cnki.issn0439-8114.2025.08.028

弧菌噬菌体裂解酶和解聚酶的研究进展

韩雯昕¹, 杨瑞冰², 孙晓雯², 王丽丽², 李晓宇², 丛聪¹

1.大连海洋大学水产与生命学院/辽宁省水生生物学重点实验室,辽宁大连 116023;
2.大连理工大学生物工程学院/动物生物技术与营养研究室,辽宁大连 116011

收稿日期:2025-04-16 出版日期:2025-08-25 发布日期:2025-09-12
通讯作者: 丛聪（1989-）,女,辽宁大连人,讲师,博士,主要从事噬菌体及噬藻体的基础应用研究及组学分析,（电子信箱）congcong@dlou.edu.cn。
作者简介:韩雯昕（2002-）,女,山西太原人,在读硕士研究生,研究方向为噬菌体及其裂解酶;
基金资助:
辽宁省自然科学基金项目(2023-BS-179)

Research progress on Vibrio bacteriophage endolysin and depolymerase

HAN Wen-xin¹, YANG Rui-bing², SUN Xiao-wen², WANG Li-li², LI Xiao-yu², CONG Cong¹

1. College of Fisheries and Life Science/Key Laboratory of Hydrobiology in Liaoning Province, Dalian Ocean University, Dalian 116023, Liaoning, China;
2. School of Bioengineering/Animal Biotechnology and Nutrition Laboratory, Dalian University of Technology, Dalian 116011, Liaoning, China

Received:2025-04-16 Published:2025-08-25 Online:2025-09-12

摘要/Abstract

摘要： 目前防治细菌的主要方式是使用抗生素,这可能会导致抗生素残留、环境污染、耐药菌增多,进而使防控难度加大。噬菌体作为细菌的天然宿敌,应用效果好、潜力巨大。噬菌体裂解酶是一种细胞壁肽聚糖水解酶或转糖苷酶,可以水解细胞外基质多糖,具有高效裂解性和高度特异性,抗菌作用显著。主要综述了近年来噬菌体,尤其是弧菌噬菌体裂解酶和解聚酶的研究现状及防控应用,旨在为开发绿色新型替抗剂的研究提供参考。

关键词: 噬菌体, 裂解酶, 解聚酶, 弧菌(Vibrio sp.)

Abstract: The use of antibiotics is primary method of combating bacterial pathogens, which has led to issues such as antibiotic residues, environmental pollution, and the increase in multidrug-resistant bacteria, thereby escalating the difficulty in infection control. As natural predators of bacteria, bacteriophages offered a promising alternative with substantial potential. Bacteriophage endolysin was a cell wall peptidoglycan hydrolase or transglycosidase, and depolymerases degraded extracellular matrix polysaccharides, which exhibited high efficacy and specificity in lysing bacterial cells. This review summarized recent advances in endolysin and depolymerase from Vibrio bacteriophages and their applications in pathogen control. The aim was to provide insights and references for researchers developing novel, eco-friendly antibacterial agents.

Key words: bacteriophage, endolysin, depolymerase, Vibrio sp.

中图分类号:

Q939.48

韩雯昕, 杨瑞冰, 孙晓雯, 王丽丽, 李晓宇, 丛聪. 弧菌噬菌体裂解酶和解聚酶的研究进展[J]. 湖北农业科学, 2025, 64(8): 183-188.

HAN Wen-xin, YANG Rui-bing, SUN Xiao-wen, WANG Li-li, LI Xiao-yu, CONG Cong. Research progress on Vibrio bacteriophage endolysin and depolymerase[J]. HUBEI AGRICULTURAL SCIENCES, 2025, 64(8): 183-188.

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弧菌噬菌体裂解酶和解聚酶的研究进展

Research progress on Vibrio bacteriophage endolysin and depolymerase

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