金黄色葡萄球菌的群体效应研究进展

doi:10.14088/j.cnki.issn0439-8114.2020.04.002

湖北农业科学 ›› 2020, Vol. 59 ›› Issue (4): 10-12.doi: 10.14088/j.cnki.issn0439-8114.2020.04.002

金黄色葡萄球菌的群体效应研究进展

洪正善, 黄郁梅, 杨柯, 曾春晖

广西中医药大学药学院,南宁 530200

收稿日期:2019-05-20 出版日期:2020-02-25 发布日期:2020-05-13
通讯作者: 春晖,教授,博士,主要从事中药炮制药理研究,(电话)13607876164(电子信箱)chhzen@163.com。
作者简介:洪正善(1993-),男,广西北海人,在读硕士研究生,研究方向为中药抗菌药理,(电话)15676723669(电子信箱)honguser@qq.com。
基金资助:
国家自然科学基金项目(81460626;81060357);广西研究生教育创新计划学位与研究生教育改革课题研究项目(JGY2014086);广西研究生教育创新计划资助项目(YJSZ201704);广西中医药大学硕士研究生创新项目(YCSY2018013)

Research progress of quorum sensing in Staphylococcus aureus

HONG Zheng-shan, HUANG Yu-mei, YANG Ke, ZENG Chun-hui

College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China

Received:2019-05-20 Online:2020-02-25 Published:2020-05-13

摘要/Abstract

摘要： 金黄色葡萄球菌(Staphylococcus aureus)中已知的群体效应系统是Agr系统和LuxS/AI-2系统,其在细菌浓度等于或大于1×10⁷ CFU/mL时会被激活,通过调控相应基因,间接或直接调控生物被膜的产生和降解、细菌毒素的分泌以及细菌的生长。综述了金黄色葡萄球菌的群体效应研究进展,旨在为今后对金黄色葡萄球菌的研究寻找新方向,金黄色葡萄球菌致病性及生物被膜的形成与金黄色葡萄球菌的群体效应系统之间存在必然联系。

关键词: 群体效应, 金黄色葡萄球菌(Staphylococcus aureus), 生物被膜

Abstract: The known group effect systems in Staphylococcus aureus are the Agr system and LuxS/AI-2 system, which are activated when the bacterial concentration is equal to or greater than 1×10⁷ CFU/mL, and indirectly or directly regulates the production and degradation, bacterial toxin secretion, and bacterial growth of the biofilm by regulating the corresponding genes. The research progress of the group effects of Staphylococcus aureus were reviewed, and a new direction for future research on Staphylococcus aureus was found. There is an inevitable relationship between the pathogenicity of Staphylococcus aureus and the formation of biofilms and the quorum sensing system of Staphylococcus aureus.

Key words: quorum sensing, Staphylococcus aureus, biofilms

中图分类号:

R378.1⁺1

洪正善, 黄郁梅, 杨柯, 曾春晖. 金黄色葡萄球菌的群体效应研究进展[J]. 湖北农业科学, 2020, 59(4): 10-12.

HONG Zheng-shan, HUANG Yu-mei, YANG Ke, ZENG Chun-hui. Research progress of quorum sensing in Staphylococcus aureus[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(4): 10-12.

参考文献

[1] RASMUSSEN R V,JR F V,SKOV R,et al.Future challenges and treatment of Staphylococcus aureus bacteremia with emphasis on MRSA[J].Future microbiology,2011,6(1):43-56.
[2] ROOIJAKKERS S H,VAN KESSEL K P,VAN STRIJP J A. Staphylococcal innate immune evasion[J].Trends in microbiology,2005,13(12):596-601.
[3] FUQUA W C,WINANS S C,GREENBERG E P.Quorum sensing in bacteria:The LuxR-LuxI family of cell density-responsive transcriptional regulators[J].Journal of bacteriology,1994, 176(2):269-275.
[4] ENGEBRECHT J,NEALSON K,SILVERMAN M.Bacterial bioluminescence:Isolation and genetic analysis of functions from Vibrio fischeri.[J].Cell,1983,32(3):773-781.
[5] CAO J G,MEIGHEN E A.Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi.[J].Journal of biological chemistry,1989,264:21670-21676.
[6] YARWOOD J M,BARTELS D J,VOLPER E M,et al.Quorum sensing in Staphylococcus aureus biofilms[J].Journal of bacteriology,2004,186(6):1838-1850.
[7] QUECK S Y,JAMESON-LEE M,VILLARUZ A E,et al.RNAIII-independent target gene control by the quorum-sensing system:Insight into the evolution of virulence regulation in Staphylococcus aureus[J].Molecular cell,2008,32(1):150-158.
[8] CASTILLO-JUÁREZ I,MAEDA T,MANDUJANO-TINOCO E A,et al. Role of quorum sensing in bacterial infections[J].World journal of clinical cases,2015,3(7):575-598.
[9] YU D,ZHAO L P,XUE T,et al.Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner[J].BMC microbiology,2012,12:288.
[10] PENG H L,NOVICK R P,KREISWIRTH B,et al.Cloning,characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus[J].Journal of bacteriology,1988, 170(9):4365-4372.
[11] THOENDEL M,KAVANAUGH J S,FLACK C E,et al.Peptide signaling in the staphylococci[J].Chemical reviews,2011,111(1):117-151.
[12] GRAY B,HALL P,GRESHAM H.Targeting agr-and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections[J].Sensors,2013,13(4):5130-5166.
[13] GEISINGER E,CHEN J,NOVICK R P.Allele-Dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus[J].Journal of bacteriology,2012,194(11):2854-2864.
[14] CHEUNG G Y C,JOO H S,CHATTERJEE S S,et al. Phenol-soluble modulins-critical determinants of staphylococcal virulence[J].Fems microbiology reviews,2014,38(4):698-719.
[15] BASSLER B L,GREENBERG E P,STEVENS A M.Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi.[J].Journal of bacteriology,1997,179(12):4043-4045.
[16] WINZER K,HARDIE K R,WILLIAMS P.LuxS and autoinducer-2:Their contribution to quorum sensing and metabolism in bacteria[J].Advances in applied microbiology,2003,53(4):291-396.
[17] 赵丽萍. 金黄色葡萄球菌中AI-2群体感应系统的调控[D].合肥:中国科学技术大学,2010.
[18] XUE T,ZHAO L P,SUN B L,et al.LuxS/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325[J].International journal of antimicrobial agents,2013,41(1):85-89.
[19] COSTERTON J W,GEESEY G G,CHENG K J.How bacteria stick[J].Scientific American,1978,238(1):86-95.
[20] LI J,XIE S Y,AHMED S,et al.Antimicrobial activity and resistance:Influencing factors[J].Frontiers in pharmacology,2017, 8:364.
[21] KUDVA I T,CORNICK N A,PLUMMER P J,et al.Virulence mechanisms of bacterial pathogens,fifth edition[M].Atlanta:American society for microbiology,2016.
[22] TOWNSLEY L,SHANK E A.Natural-product antibiotics:Cues for modulating bacterial biofilm formation[J].Trends in microbiology,2017,25(12):1016-1026.
[23] KIRAN M D,ADIKESAVAN N V,CIRIONI O,et al.Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening[J].Molecular pharmacology,2008,73(5):1578-1586.
[24] AUDRETSCH C,LOPEZ D,SRIVASTAVA M,et al.A semi-quantitative model of quorum-sensing in Staphylococcus aureus,approved by microarray meta-analyses and tested by mutation studies[J].Molecular biosystems,2013,9(11):2665-2680.
[25] FOSTER T J,GEOGHEGAN J A,GANESH V K,et al.Adhesion,invasion and evasion:The many functions of the surface proteins of Staphylococcus aureus[J].Nature reviews microbiology,2014,12(1):49-62.
[26] LAUDERDALE K J,BOLES B R,CHEUNG A L,et al.Interconnections between sigma B,agr,and proteolytic activity in Staphylococcus aureus biofilm maturation[J].Infection & immunity,2009,77(4):1623-1635.
[27] DASTGHEYB S S,VILLARUZ A E,LE K Y,et al.Role of phenol-soluble modulins in formation of Staphylococcus aureus biofilms in synovial fluid[J].Infection & immunity,2015,83(7):2966-2975.
[28] RUTHERFORD S T,BASSLER B L.Bacterial quorum sensing:Its role in virulence and possibilities for its control[J]. Cold spring harbor perspectives in medicine,2012,2(11):705-709.
[29] ROUX A,TODD D A,VELÁZQUEZ J V,et al. CodY-Mediated regulation of the Staphylococcus aureus agr system integrates nutritional and population density signals[J].Journal of bacteriology,2014,196(6):1184-1196.
[30] BEENKEN K E,MRAK L N,GRIFFIN L M,et al.Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation[J].PloS one,2010,5(5):e10790.
[31] ZHAO L P,XUE T,SHANG F,et al.Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence[J].Infection & immunity,2010,78(8):3506-3515.
[32] RASIGADE J P, TROUILLET-ASSANT S,FERRY T,et al.PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts[J].PLoS one,2013,8:e63176.
[33] WANG R,BRAUGHTON K R,KRETSCHMER D,et al.Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA[J].Nat Med,2007,13:1510-1514.
[34] CASSAT J E,HAMMER N D,CAMPBELL J P,et al.A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis[J].Cell host microbe,2013,13:759-772.

金黄色葡萄球菌的群体效应研究进展

Research progress of quorum sensing in Staphylococcus aureus

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价