噬菌体仲裁通讯系统的研究进展

doi:10.14088/j.cnki.issn0439-8114.2021.09.001

湖北农业科学 ›› 2021, Vol. 60 ›› Issue (9): 5-9.doi: 10.14088/j.cnki.issn0439-8114.2021.09.001

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噬菌体仲裁通讯系统的研究进展

焦文豪, 徐冰红, 刘静, 刘培源, 严汉池

天津大学生命科学学院,天津 300072

收稿日期:2020-06-01 发布日期:2021-05-14
作者简介:焦文豪（1993-）,男,河北石家庄人,在读硕士研究生,研究方向为结构生物学,（电话）13820935955（电子信箱）wenhaojiao75@163.com。
基金资助:
真核生物CSC/OSCA家族阳离子通道的结构与功能（31870742）; 与EB病毒肿瘤发生密切相关的潜伏膜蛋白的结构与功能（31470731）

Research progress of phage arbitrium communication system

JIAO Wen-hao, XU Bing-hong, LIU Jing, LIU Pei-yuan, YAN Han-chi

School of Life Sciences,Tianjin University,Tianjin 300072,China

Received:2020-06-01 Published:2021-05-14

摘要/Abstract

摘要： 温和噬菌体在感染宿主期间可根据种群密度进入裂解或溶原周期。近年来,在针对枯草芽孢杆菌感染过程的SPbeta噬菌体中发现了一种决定裂解-溶原过程的通讯系统,该通讯系统被称为仲裁通讯系统。仲裁通讯系统由aimR、aimP、aimX 3个噬菌体基因组成,其中aimR编码的AimR蛋白是仲裁通讯系统的关键蛋白。仲裁肽运至细胞内与AimR蛋白结合,解除AimR蛋白对aimX基因的调控作用,使噬菌体进入溶原周期。对AimR蛋白的结构特征、肽作用机制等进行了综述,以期为这种通讯系统的深入研究以及利用枯草芽孢杆菌进行病害防治提供参考。

关键词: 温和噬菌体, 裂解-溶原, 仲裁肽, AimR

Abstract: During the infection of the host, the temperate bacteriophages can enter lytic or lysogenic life cycles according to the population density. In recent years, for SPbeta phages in Bacillus subtilis infection process, a communication system was found to determine the process of lysis-lysogeney. The communication system is called arbitrium communication system. Arbitrium communication system is composed of three phage genes：aimR,aimP,aimX. The AimR protein encoded by the aimR gene is the key protein of the arbitrium communication system. The arbitrium peptide is transported into the cell to bind with the AimR protein, which releases the regulation effect of the AimR protein on the aimX gene, allowing the bacteriophage to enter the lysogenic cycle. The structural characteristics of AimR and the mechanism of peptide action were reviewed, in order to provide valuable reference information for the in-depth study of this communication system and for disease control by Bacillus subtilis.

Key words: temperate bacteriophages, lysis-lysogeny, arbitrium peptide, AimR

中图分类号:

焦文豪, 徐冰红, 刘静, 刘培源, 严汉池. 噬菌体仲裁通讯系统的研究进展[J]. 湖北农业科学, 2021, 60(9): 5-9.

JIAO Wen-hao, XU Bing-hong, LIU Jing, LIU Pei-yuan, YAN Han-chi. Research progress of phage arbitrium communication system[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(9): 5-9.

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噬菌体仲裁通讯系统的研究进展

Research progress of phage arbitrium communication system

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