Melatonin inhibits zearalenone-induced apoptosis of porcine ovarian granulosa cells

doi:10.14088/j.cnki.issn0439-8114.2020.22.031

HUBEI AGRICULTURAL SCIENCES ›› 2020, Vol. 59 ›› Issue (22): 151-154.doi: 10.14088/j.cnki.issn0439-8114.2020.22.031

• Animal Husbandry & Veterinary Medicine • Previous Articles Next Articles

Melatonin inhibits zearalenone-induced apoptosis of porcine ovarian granulosa cells

ZHOU Jia-wei¹, WU Jun-jing¹, QIAO Mu¹, WANG Xiao-zhong², LIU Gui-sheng¹, MEI Shu-qi¹, PENG Xian-wen¹

1. Hubei Key Laboratory of Animal Embryo and Molecular Breeding/Institute of Animal Science and Veterinary Medicine,Hubei Academy of Agricultural Sciences,Wuhan 430063,China;
2. Animal Disease Prevention and Control Center of Yichang City,Yichang 443000,Hubei,China

Received:2020-07-02 Online:2020-11-25 Published:2020-12-30

Abstract

Abstract: Primary cultured porcine ovarian granulosa cells were used as a model to explore the effect of ZEA on the apoptosis of porcine ovarian granulosa cells,and to determine whether melatonin (MT) regulated the effect of ZEA on the apoptosis of porcine ovarian granulosa cells.The results showed that3 and10 μmol/L ZEA had no significant effect on the apoptosis of porcine ovarian granulosa cells,but30,50 and100 μmol/L ZEA significantly promoted the apoptosis of porcine ovarian granulosa cells,and showed a dose-effect relationship;It was found that 0.1 and1 μmol/L MT partially inhibited30 μmol/L ZEA-induced apoptosis of porcine ovarian granulosa cells and increased cell viability.

Key words: zearalenone, melatonin, porcine ovarian granulosa cells, cell apoptosis

CLC Number:

S858.28

ZHOU Jia-wei, WU Jun-jing, QIAO Mu, WANG Xiao-zhong, LIU Gui-sheng, MEI Shu-qi, PENG Xian-wen. Melatonin inhibits zearalenone-induced apoptosis of porcine ovarian granulosa cells[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(22): 151-154.

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Melatonin inhibits zearalenone-induced apoptosis of porcine ovarian granulosa cells

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