Abstract: The alleviation efficacy of Cynanchum bungei on high-fat-induced obesity mice was studied. Thirty male mice were randomly divided into three groups, fed control diet （Con）, high-fat diet （HF, 45% energy from fat） and high-fat diet containing with Cynanchum bungei （HBS）. After feeding for 9 weeks, glucose tolerance was tested, body weight and organ weight were measured, plasma concentration of glucose and triglyceride were measured using respective commercial assay kits, HE staining and oil red staining were used to observe the number and size of adipose and muscle cells and the lipid content in liver. The results showed that fed mice with Cynanchum bungei significantly alleviated glucose intolerance. The body weight, brown fat weight, epididymal fat weight, brown fat index and epididymal fat index were significantly （P<0.05） reduced in HBS group, also the concentration of glucose and triglyceride in plasma were significantly decreased （P<0.05）. The lipid content in liver and the size of adipocyte were decreased in HBS group.

Key words: Cynanchum bungei, obesity, alleviate, lipid metabolism