肥胖相关基因与脂肪代谢调控关系的研究进展

doi:10.14088/j.cnki.issn0439-8114.2018.02.003

湖北农业科学 ›› 2018, Vol. 57 ›› Issue (2): 14-17.doi: 10.14088/j.cnki.issn0439-8114.2018.02.003

肥胖相关基因与脂肪代谢调控关系的研究进展

辛友志^a, 郭彦^a, 李军^b, 肖荣^a, 周国利^a

聊城大学,a.生命科学学院;b.药学院,山东聊城 252059

收稿日期:2017-07-31 出版日期:2018-01-25 发布日期:2018-01-10
通讯作者: 周国利（1975-）,男,内蒙古赤峰人,副教授,博士,硕士生导师,主要从事动物遗传育种与功能基因的遗传调控,（电子信箱）glzhou1975@163.com。
作者简介:辛友志（1994-）,男,山东日照人,在读硕士研究生,研究方向为动物遗传育种与功能基因的遗传调控,（电话）18766352469（电子信箱）569690021@qq.com
基金资助:
国家自然科学基金项目（31571274）; 山东省自然科学基金项目（ZR2015CM025）

Research Advances of the Relationship between Obesity Associated Gene and Fat Metabolism Regulation

XIN You-zhi^a, GUO Yan^a, LI Jun^b, XIAO Rong^a, ZHOU Guo-li^a

a.College of Life Science;b.College of Pharmacy,Liaocheng University,Liaocheng 252059,Shandong,China

Received:2017-07-31 Online:2018-01-25 Published:2018-01-10

摘要/Abstract

摘要： 肥胖的形成与脂肪代谢密切相关,研究表明,脂肪与肥胖相关基因（Fat mass and obesity associated gene,FTO）在脂肪代谢调控过程中发挥了重要作用。综述了FTO基因的单核苷酸多态性位点（Single nucleotide polymorphisms,SNPs）与相关联基因的互作、时空表达特异性和能量调节以及其在多条信号通路中的调控机制的相关研究进展。

关键词: 脂肪与肥胖相关基因, 脂肪代谢, 调控机制

Abstract: Obesity has become a hot focus on problems,the formation of obesity is closely related to fat metabolism. Studies have shown that fat mass and obesity associated gene（FTO） has played an important role in the process of fat metabolism regulation. This paper reviewed the FTO gene single nucleotide polymorphisms（SNPs）, interactions with associated gene, spatial and temporal expression character and energy regulation,and its regulatory mechanism in multiple signaling pathways, with the aim of expounding the relationship between the FTO gene and fat metabolism regulation, and provides the ideas and matting for the future study.

Key words: fat mass and obesity associated gene, fat metabolism, regulation mechanism

中图分类号:

辛友志, 郭彦, 李军, 肖荣, 周国利. 肥胖相关基因与脂肪代谢调控关系的研究进展[J]. 湖北农业科学, 2018, 57(2): 14-17.

XIN You-zhi, GUO Yan, LI Jun, XIAO Rong, ZHOU Guo-li. Research Advances of the Relationship between Obesity Associated Gene and Fat Metabolism Regulation[J]. HUBEI AGRICULTURAL SCIENCES, 2018, 57(2): 14-17.

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肥胖相关基因与脂肪代谢调控关系的研究进展

Research Advances of the Relationship between Obesity Associated Gene and Fat Metabolism Regulation

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