转录中介体复合物的研究进展

doi:10.14088/j.cnki.issn0439-8114.2020.03.001

摘要/Abstract

摘要： 转录中介体复合物（Mediator complex）广泛存在于真核生物中,在进化上高度保守,是一个具有模块化组织的大复合物,参与转录因子与RNA聚合酶Ⅱ之间的信息传递。中介体复合物的主要功能是通过其特定亚基与不同信号通路激发的转录因子相互作用,调节下游基因的表达。此外,中介体复合物还与各种辅因子相互作用,参与转录延伸、mRNA输出及选择性剪切等过程,从而调控细胞的各种生理功能。中介体复合物与疾病的密切联系使得将中介体作为靶标研究疾病的治疗方法成为可能。以中介体复合物的结构为基础,重点介绍了中介体复合物在基因表达调控中的分子机制及功能,以期为后续研究提供参考。

关键词: 中介体复合物（Mediator complex）, 结构, 分子机制, 功能

Abstract: The mediator complex, a highly conserved large complex with modular tissue, is widely distributed in eukaryotes and is involved in the transmission of information between transcription factors and RNA polymerase II. The main function of the mediator complex is to regulate the expression of downstream genes by interacting with transcription factors stimulated by different signaling pathways. In addition, the mediator complex interacts with various cofactors to participate in processes such as transcriptional elongation, mRNA export, and selective splicing, thereby controlling various physiological functions of the cell. The close relationship between mediator complexes and disease makes it possible to study the treatment of disease with mediator as a target. Based on the structure of the mediator complex, the molecular mechanism and function of the mediator complex in the regulation of gene expression were introduced, in order to provide reference for the following research.

Key words: mediator complex, structure, molecular mechanism, function

中图分类号:

王雯, 刘坤. 转录中介体复合物的研究进展[J]. 湖北农业科学, 2020, 59(3): 5-8.

WANG Wen, LIU Kun. Resarch progress of transcription mediator complex[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(3): 5-8.

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