多糖的化学修饰及其结构鉴定研究进展

doi:10.14088/j.cnki.issn0439-8114.2021.03.002

摘要/Abstract

摘要： 多糖是一种自然界广泛存在的生物高分子聚合物,具有广泛的药理活性。但天然多糖并非都具有理想的生物活性,多糖结构决定其生理功能,对多糖进行化学修饰能提高其药理活性,也有助于研究多糖的构效关系。多糖衍生化发生成功与否主要通过傅里叶变换红外光谱（Fourier transform infrared spectroscopy,FT-IR）和核磁共振（Nuclear magnetic resonance,NMR）图谱进行鉴定。对近5年来多糖衍生化的方法及衍生化后的FT-IR和NMR图谱特征进行了综述,旨在对多糖的化学修饰及其结构鉴定提供参考和借鉴,以期促进多糖生物学的发展。

关键词: 多糖, 化学修饰, 结构鉴定, 核磁共振

Abstract: Polysaccharide is a kind of biopolymer, which widely existing in nature, and possessing extensive pharmacological activities. However, not all original polysaccharides from natural products have ideal bioactivity, which depends on their structures. Chemical modification of polysaccharides will be benefit to improve their bioactivity and helpful to study their structure-activity relationship. Whether derivatives were prepared successfully or not, could be proven by Fourier transform infrared （FT-IR） spectra and Nuclear magnetic resonance （NMR spectra）. Methods of chemical modification of polysaccharide and their structural characterizations by FT-IR and Nuclear magnetic resonance NMR spectroscopy were mainly summarized in this paper in order to provide some references,promote the development of polysaccharide biology.

Key words: polysaccharides, chemical modification, structural characterization, nuclear magnetic resonance

中图分类号:

O629.12

谢苗, 亓小妮, 吴杨洋, 张鑫, 杜秀菊. 多糖的化学修饰及其结构鉴定研究进展[J]. 湖北农业科学, 2021, 60(3): 11-17.

XIE Miao, QI Xiao-ni, WU Yang-yang, ZHANG Xin, DU Xiu-ju. Research progress on chemical modification of polysaccharides and its structure identification[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(3): 11-17.

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