肠外致病性大肠杆菌研究

doi:10.14088/j.cnki.issn0439-8114.2022.16.028

湖北农业科学 ›› 2022, Vol. 61 ›› Issue (16): 147-150.doi: 10.14088/j.cnki.issn0439-8114.2022.16.028

肠外致病性大肠杆菌研究

吴桐忠, 张倩, 张星星, 钟发刚, 何延华, 韩猛立, 黄新

新疆农垦科学院省部共建绵羊遗传改良与健康养殖国家重点实验室,新疆石河子 832000

收稿日期:2022-05-28 出版日期:2022-08-25 发布日期:2022-09-14
通讯作者: 韩猛立（1980-）,男,副研究员,硕士,主要从事动物传染病诊断与防治研究,（电话）13519932980（电子信箱）hanmenglimm@163.com;黄新（1973-）,男,副研究员,硕士,主要从事动物传染病诊断与防治研究,（电子信箱）ahx512@163.com。
作者简介:吴桐忠（1970-）,男,新疆石河子人,助理研究员,主要从事动物传染病诊断与防治研究。
基金资助:
新疆兵团区域创新引导计划项目（2018BB036）; 省部共建绵羊遗传改良与健康养殖国家重点实验室优秀中青年人才培养引导计划项目（SKLSGIHP2016A02; SKLSGIHP2017A03）; 新疆兵团重大科技计划项目（2017AA006）; 新疆兵团重点领域科技攻关计划项目（2019AB029）; 新疆兵团国际科技合作计划项目（2019BC004）

Research on extraintestinal pathogenic Escherichia coli

WU Tong-zhong, ZHANG Qian, ZHANG Xing-xing, ZHONG Fa-gang, HE Yan-hua, HAN Meng-li, HUANG Xin

State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi 832000, Xinjiang, China

Received:2022-05-28 Online:2022-08-25 Published:2022-09-14

摘要/Abstract

摘要： 肠外致病性大肠杆菌（Extraintestinal pathogenic E. coli,ExPEC）是近年来出现的引起人和动物免疫系统受损的主要临床病原体,由不同血清型且不发生交叉反应的菌株引起,部分菌株具有高度耐药性是导致感染严重程度的主要因素之一。对目前ExPEC的主要感染类型、毒力因子以及抵御感染的潜在手段进行了概述。

关键词: 肠外致病性大肠杆菌, 毒力因子, 免疫反应

Abstract: Extraintestinal pathogenic E. coli （ExPEC） was the main clinical pathogen that had appeared in recent years to cause damage to the immune system of humans and animals. It consisted of a large number of different serotypes that did not cross-react. The seriousness of the infection was due to the fact that most of the infecting bacteria were highly antibiotic resistant. The main types of infection involved in ExPEC, virulence factors, and potential means to combat the infections were discussed.

Key words: extraintestinal pathogenic E.coli, virulence factor, immune response

中图分类号:

S852.6

吴桐忠, 张倩, 张星星, 钟发刚, 何延华, 韩猛立, 黄新. 肠外致病性大肠杆菌研究[J]. 湖北农业科学, 2022, 61(16): 147-150.

WU Tong-zhong, ZHANG Qian, ZHANG Xing-xing, ZHONG Fa-gang, HE Yan-hua, HAN Meng-li, HUANG Xin. Research on extraintestinal pathogenic Escherichia coli[J]. HUBEI AGRICULTURAL SCIENCES, 2022, 61(16): 147-150.

参考文献

[1] BIRAN D,RON E Z.Extraintestinal pathogenic Escherichia coli [J].Current topics in microbiology and immunology,2018,416:149-161.
[2] RON E Z.Host specificity of septicemic Escherichia coli: Human and avian pathogens[J]. Current opinion in microbiology, 2006, 9(1):28-32.
[3] NIELSEN D W, RICKER N,BARBIERI N L,et al.Outer membrane protein A (OmpA) of extraintestinal pathogenic Escherichia coli[J]. BMC research notes, 2020, 13(1): 51.
[4] KRISHNAN S, CHANG A C, HODGES J, et al. Serotype O18 avian pathogenic and neonatal meningitis Escherichia coli strains employ similar pathogenic strategies for the onset of meningitis[J].Virulence, 2015, 6(8):777-786.
[5] NICHOLSON B A, WANNEMUEHLER Y M, LOGUE C M, et al.Complete genome sequence of the Avian-pathogenic Escherichia coli strain APEC O18[J]. Genome announcements,2016,4(6):1213-1216.
[6] MALUTA R P, LOGUE C M, CASAS M R, et al.Overlapped sequence types (STs) and serogroups of avian pathogenic (APEC) and human extra-intestinal pathogenic (ExPEC) Escherichia coli isolated in Brazil[J]. PLoS ONE, 2014, 9(8):e105016.
[7] ZHUGE X K, JIANG J W, PAN Z H, et al.Comparative genomic analysis shows that avian pathogenic Escherichia coli isolate IMT5155 (O2:K1:H5; ST complex 95, ST140) shares close relationship with ST95 APEC O1:K1 and human ExPEC O18:K1 strains[J]. PLoS ONE, 2014, 9(11): 112048.
[8] MANGES A R.Escherichia coli and urinary tract infections: The role of poultry-meat[J]. Clinical microbiology and infection, 2016, 22(2):122-129.
[9] DZIVA F, HAUSER H, CONNOR T R, et al.Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms[J]. Infection and immunity, 2013, 81(3):838-849.
[10] HUJA S, OREN Y, TROST E, et al.Genomic avenue to avian colisepticemia[J]. MBio, 2015, 6(1):e01681-14.
[11] CORDONI G, WOODWARD M J, WU H, et al.Comparative genomics of European avian pathogenic E. coli (APEC)[J]. BMC genomics, 2016, 17(1):960.
[12] KJELSTRUP C K, ARNESEN L P, GRANQUIST E G, et al.Characterization of Escherichia coli O78 from an outbreak of septicemia in lambs in Norway[J]. Veterinary microbiology, 2013, 166(1-2): 276-280.
[13] 顾晓晓. 新疆部分地区牛、羊源肠外致病性大肠杆菌分离鉴定、分子分型及耐药性研究[D]. 新疆石河子:石河子大学,2020.
[14] 柴迎锦,顾晓晓,邬琴,等.肠外致病性大肠埃希菌毒力因子研究进展[J].动物医学进展,2020,41(2):80-84.
[15] 韩和祥. 四川省部分规模化肉牛养殖场致犊牛腹泻大肠杆菌的血清型鉴定与耐药性分析[J]. 黑龙江畜牧兽医,2019(4):107-109.
[16] 宋晓莉. 江苏部分地区肉羊源大肠杆菌的分子流行病学及其部分特性研究[D].江苏扬州:扬州大学,2019.
[17] WIJETUNGE D S, GONGATI S, DEBROY C, et al.Characterizing the pathotype of neonatal meningitis causing Escherichia coli (NMEC)[J]. BMC Microbiology, 2015,15: 211.
[18] WIJETUNGE D S, KATANI R, KAPUR V, et al.Complete genome sequence of Escherichia coli strain RS218 (O18:H7:K1), associated with neonatal meningitis[J]. Genome announcements, 2015, 3(4): e00804-15.
[19] JACODSEN S M, STICKLER D J, MOBLEY H L, et al. Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis[J]. Clinical microbiology reviews,2008,21:26-59.
[20] FOXMAN B.Urinary tract infection syndromes: Occurrence, recurrence, bacteriology, risk factors, and disease burden[J]. Infectious disease clinics of North America, 2014, 28(1):1-13.
[21] BOGEMA D R,MCKINNON J,LIU M,et al.Whole-genome analysis of extraintestinal Escherichia coli sequence type 73 from a single hospital over a 2 years period identified different circulating clonal groups[J].Microbial genomics,2020,6(1):e000255.
[22] BADER M S, LOEB M, LETO D, et al.Treatment of urinary tract infections in the era of antimicrobial resistance and new antimicrobial agents[J].Journal of postgraduate medicine,2020,132(3):234-250.
[23] BARBER A E,FLEMingB A,MULVRY M A.Similarly lethal strains of extraintestinal pathogenic Escherichia coli trigger markedly diverse host responses in a zebrafish model of sepsis[J].mSphere,2016,1(2):e00062-16.
[24] OLIVERIRA J, REYGAERT WC.Gram negative bacteria[M]. In StatPearls,Treasure Island (FL): StatPearls Publishing,2020.
[25] TAIEB F, PETIT C, NOUGAYREDE J P, et al.The enterobacterial genotoxins: Cytolethal distending toxin and colibactin[J]. Ecosal plus,2016,7(1):DOI:10.1128/ecosalplus.ESP-0008-2016.
[26] WIJETUNGE D S, KARUNATHILAKE K H, CHAUDHARI A, et al.Complete nucleotide sequence of pRS218, a large virulence plasmid, that augments pathogenic potential of meningitis-associated Escherichia coli strain RS218[J]. BMC Microbiol, 2014, 14:203.
[27] KALITA A, HU J, TORRES A G.Recent advances in adherence and invasion of pathogenic Escherichia coli [J]. Current infectious disease reports, 2014, 27(5): 459-464.
[28] WANG S, LIU X, XU X, et al.Escherichia coli type III secretion system 2 (ETT2) is widely distributed in avian pathogenic Escherichia coli isolates from Eastern China[J]. Epidemiology and infection, 2016,144(13):2824-2830.
[29] HU Y, HUANG H, CHENG X, et al.A global survey of bacterial type III secretion systems and their effectors[J]. Environmental microbiology, 2017,19(10):3879-3895.
[30] WANG S, LIU X, XU X, et al. Escherichia coli type III secretion system 2 ATPase EivC Is Involved in the motility and virulence of avian pathogenic Escherichia coli[J]. Front microbiol, 2016, 7: 1387.
[31] SHULMAN A, YAIR Y, BIRAN D, et al. The Escherichia coli type III secretion system 2 has a global effect on cell surface[J]. MBio, 2018, 9(4):e01070-18.
[32] PHAN M D, PETERS K M, SARKAR S, et al.The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone[J]. PLoS genetics, 2013,9(10):e1003834.
[33] SARKAR S,ULETT G C, TOTSIKA M, et al.Role of capsule and O antigen in the virulence of uropathogenic Escherichia coli[J]. PLoS ONE, 2014, 9(4): e94786.
[34] THOMASSIN J L,LEE M J,BRANNON J R,et al.Both group 4 capsule and lipopolysaccharide O-antigen contribute to enteropathogenic Escherichia coli resistance to human alpha-defensin 5[J]. PLoS ONE, 2013, 8(12): e82475.
[35] CABONI M, PEDRON T, ROSSI O, et al.An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei[J]. PLoS Pathog, 2015, 11(3): e1004749.
[36] BIRAN D, ROSENSHINE I, RON E Z.Escherichia coli O-antigen capsule (group 4) is essential for serum resistance[J]. Research in microbiology, 2020, 171(2): 99-101.
[37] DZIVA F, HAUSER H, CONNOR T R, et al.Sequencing and functional annotation of avian pathogenic Escherichia coli serogroup O78 strains reveal the evolution of E. coli lineages pathogenic for poultry via distinct mechanisms[J]. Infection and immunity, 2013, 81(3): 838-849.
[38] HUJA S,OREN Y,BIRAN D,et al.Fur is the master regulator of the extraintestinal pathogenic Escherichia coli response to serum[J]. MBio, 2014, 55(4):e01460-14.
[39] OTTO A, BIRAN D, SURA T, et al.Proteomics of septicemic Escherichia coli proteomics[J]. Proteomics clinical applications, 2016,10(9-10):1020-1024.

肠外致病性大肠杆菌研究

Research on extraintestinal pathogenic Escherichia coli

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