The application profile of bacteriophage lysins

doi:10.14088/j.cnki.issn0439-8114.2019.10.001

Abstract

Abstract: More recently, the original application of phage as therapeutics to treat human and animal infections has been rekindled, particularly in an era where antibiotic resistance has become so problematic. Bacteriophage lysins,which are peptidoglycan hydrolases encoded by double-stranded DNA bacteriophage, are produced in phage-infected bacterial cells toward the end of the lytic cycle. It was proved that the phage lysins exhibited high activity against bacteria, narrow antibacterial spectrum, and apparent safety in vitro and vivo experiments. Those paved solid foundation for further exploration of their application. A review on the structure and mode of action of lysins and their application were presented.

Key words: bacteriophage, lysin, antibiotic resistant bacteria

CLC Number:

S562

YAN Jing, HU Shen-cai. The application profile of bacteriophage lysins[J]. HUBEI AGRICULTURAL SCIENCES, 2019, 58(10): 5-8.

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