Okaramines：A group of natural insecticidal indole alkaloids with new mode of action

doi:10.14088/j.cnki.issn0439-8114.2019.23.020

Abstract

Abstract: Okaramines, produced by some species of Penicillium spp. and Aspergillus spp., are a group of natural indole alkaloids with new mode of action of insecticidal activity. Up to now, more than 20 Okaramine analogues have been discovered, and most of them showed insecticidal activity with Bombyx mori as target insect. Of the Okaramine analogues, Okaramine B showed the highest insecticidal activity. The studies on structure-activity relationship showed that the azetidine and azocine rings and the methoxy group were highly related to the insecticidal activity. Okaramines can activate the glutamate gated chloride channel in insect neurons. The okaramines were biosynthesized in fungi with tryptoan as the starting unit. Okaramines were diversely biosynthesized through the catalysis by nonribosomal peptide synthase, flavin-dependent monooxygenase, prenyltransferase, P450 monooxygenase, α-ketoglutarate-dependent dioxygenase, and methyltransferase, etc. encoded by clustered biosynthetic genes as clarified through genome mining, gene deletion and inactivation, and heterogenous expression.

Key words: Okaramine, producing microorganism, insecticidal activity, structure-activity relationship, mode of action, biosynthesis

CLC Number:

Q599

ZHANG Zun-xia, WANG Yue-yin, ZHANG Ya-ni, ZHANG Zhi-gang, WANG Kai-mei. Okaramines：A group of natural insecticidal indole alkaloids with new mode of action[J]. HUBEI AGRICULTURAL SCIENCES, 2019, 58(23): 86-90.

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