HUBEI AGRICULTURAL SCIENCES ›› 2019, Vol. 58 ›› Issue (23): 139-141.doi: 10.14088/j.cnki.issn0439-8114.2019.23.033

• Animal Husbandry & Veterinary Medicine • Previous Articles     Next Articles

Effects of Cep164 gene deletion on embryonic mouse brain development

WANG Chun-hua   

  1. School of Life Science and Technology,Mudajiang Normal University,Mudanjiang 157000,Heilongjiang,China
  • Received:2019-03-20 Online:2019-12-10 Published:2019-12-18

Abstract: To reveal the function of Cep164 gene in mouse brain development, the expression level of Foxg1,Otx2,Gbx2,Fgf8 and En1 in embryonic brain with Cep164 gene deletion was detected by in situ hybridization experiment. The results showed that the expression of Gbx2 and Otx2 in the brain, and Fgf8 in the midbrain-hindbrain boundary, were no significant change in the Cep164 mutation embryonic mice, compared with wild type. But the expression of Foxg1 in telencephalic vesicles, the Fgf8 in anterior neural ridge, the Otx2 in eye and olfaction plate, and En1 in ventral midbrain and anterior hindbrain decreased. The all results reveal Cep164 is an important gene to maintain the normal brain development. Cep164 gene mutation could cause forebrain dysplasia, mainly affect olfaction and vision.

Key words: Cep164, gene deletion, embryonic mouse, brain development, in situ hybridization

CLC Number: