Research progress on the effects of histone deacetylase inhibitors on in vitro developmental competence of nuclear transfer embryos

doi:10.14088/j.cnki.issn0439-8114.2020.18.001

Abstract

Abstract: Histone deacetylase inhibitor （HDACi） is a class of compounds that can interfere with histone deacetylase to control the tightness of DNA binding to histones and play a role, which can increase the degree of histones acetylation in cells and improve the expression level of acetylated genes. In recent years, the researches on HDACi promoting epigenetic reprogramming of donor cells and nucleartransfer embryos and regulating the genes expression in higher animals have attracted much attention. The effects of HDACi on the in vitro developmental competence of nuclear transfer embryos are mainly described, in order to provide reference for improving the production efficiency of cloned embryos.

Key words: histone deacetylase inhibitors, nuclear transfer, embryos, developmental competence

CLC Number:

Q132.4

LYU Ling-yan, WU Yong-shao, ZHANG Jia-qing, SUN Ru-yu, WANG Yan-ling, PAN Tian-biao, CHEN Bao-jian, XIE Bing-kun. Research progress on the effects of histone deacetylase inhibitors on in vitro developmental competence of nuclear transfer embryos[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(18): 5-8.

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