Research progress on chemical compositions and pharmacological effects of Capsicum annuum L.

doi:10.14088/j.cnki.issn0439-8114.2021.15.001

Abstract

Abstract: Capsicum annuum L. has anti-tumor, pain relief, hypoglycemic and hypolipidemic, anti-fatigue, protecting gastrointestinal system and cardiovascular systems, and other pharmacological effects. The correlational research of chemical compositions, pharmacological effects and clinical applications of Capsicum annuum L. was summarized and analyzed, in order to provide references for its further research, development and utilization.

Key words: Capsicum annuum L., chemical composition, pharmacological effect, clinical application

CLC Number:

S641.3

DENG Wen-yi, WEN Jiang-ping. Research progress on chemical compositions and pharmacological effects of Capsicum annuum L.[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(15): 5-10.

References

[1] BOSLAND P W, COON D, REEVES G.“Trinidad Moruga Scorpion” pepper is the world’s hottest measured chile pepper at more than two million Scoville heat units[J]. HortTechnology, 2012, 22(4): 534-538.
[2] KOZUKUE N, HAN J S, KOZUKUE E, et al.Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry[J]. Journal of agricultural and food chemistry, 2005, 53: 9172-9181.
[3] BOSLAND P W, BARAL J.“Bhut Jolokia”-The world’s hottest known chile pepper is a putative naturally occurring interspecific hybrid[J]. HortScience, 2007, 42: 222-224.
[4] DENG M H,WEN J F,ZHU H S,et al.The hottest pepper variety in China[J]. Genetic resources and crop evolution,2009,56:605-608.
[5] 李海龙, 张俊清, 赖伟勇, 等. 海南黄灯笼椒与不同品种辣椒的辣椒素含量测定[J]. 中国野生植物资源, 2012, 31(4):32-34.
[6] WAHYUNI Y, BALLESTER A R, SUDARMONOWATI E, et al.Secondary metabolites of Capsicum species and their importance in the human diet[J]. Journal of natural products,2013,76:783-793.
[7] KIM J S,AN C G,PARK J S,et al.Carotenoid profiling from 27 types of paprika(Capsicum annuum L.) with different colors,shapes and cultivation methods[J]. Food chemistry,2016,201:64-71.
[8] GUZMAN I, HAMBY S, ROMERO J, et al.Variability of carotenoid biosynthesis in orange colored Capsicum spp.[J]. Plant science, 2010, 179: 49-59.
[9] ANTONIO A S,WIEDEMANN L S M,VEIGAJUNIOR V F. The genus Capsicum:A phytochemical review of bioactive secondary metabolites[J]. The royal society of chemistry,2018,8:25767-25784.
[10] VAN ZONNEVELD M,RAMIREZ M,WILLIAMS D E,et al.Screening genetic resources of Capsicum peppers in their primary center of diversity in Bolivia and Peru[J]. PLoS one,2015,10: e0134663.
[11] MECKELMANN S W,JANSEN C,RIEGEL D W,et al.Phytochemicals in native Peruvian Capsicum pubescens (Rocoto)[J]. The journal european food research and technology, 2015, 241: 817-825.
[12] MARÍN A, FERRERES F, TÓMAS-BARBERÁN F A, et al. Characterization and quantitation of antioxidant constituents of sweet pepper (Capsicum annuum L.)[J]. Journal of agricultural and food chemistry, 2014, 52: 3861-3869.
[13] BAE H, JAYAPRAKASHA G K, CROSBY K, et al.Ascorbic acid, capsaicinoid and flavonoid aglycone concentrations as a function of fruit maturity stage in greenhouse-grown peppers[J]. Journal of food composition and analysis, 2014, 33: 195-202.
[14] AGOSTINI-COSTA T S, DA SILVA GOMES I, DE MELO L A M P, et al. Carotenoid and total vitamin C content of peppers from selected Brazilian cultivars[J]. Journal of food composition and analysis, 2017, 57: 73-79.
[15] KANTAR M B, ANDERSON J E, LUCHT S A, et al.Vitamin variation in Capsicum spp. provides opportunities to improve nutritional value of human diets[J]. PLoS one,2016,11(8):e0161464.
[16] PERLA V, NIMMAKAYALA P, NADIMI M, et al.Vitamin C and reducing sugars in the world collection of Capsicum baccatum L. genotypes[J]. Food chemistry, 2016, 202: 189-198.
[17] EGGINK P M, MALIEPAARD C, TIKUNOV Y, et al.A taste of sweet pepper: Volatile and non-volatile chemical composition of fresh sweet pepper (C. annuum) in relation to sensory evaluation of taste[J]. Food chemistry, 2012, 132: 301-310.
[18] BOGUSZ JUNIOR S, MARÇO P H, VALDERRAMA P, et al. Analysis of volatile compounds in Capsicum spp. by headspace solidphase microextraction and GC×GCTOFMS[J]. Analytical methods, 2015, 7:521-529.
[19] CUEVAS-GLORY L, SOSA-MOGUEL O, PINO J, et al.GC-MS characterization of volatile compounds in habanero pepper (Capsicum chinense Jacq.) by optimization of headspace solid-phase microextraction conditions[J]. Food analytical methods,2015,8: 1005-1013.
[20] MORENO E,FITA A,GONZÁLEZ-MAS M C,et al. HS-SPME study of the volatile fraction of Capsicum accessions and hybrids in different parts of the fruit[J]. Scientia horticulturae,2012,135: 87-97.
[21] HUANG S P, CHEN J C, WU C C, et al.Capsaicin-induced apoptosis in human hepatoma HepG2 cells[J]. Anticancer research, 2009, 29: 165-174.
[22] WANG F, ZHAO J, LIU D, et al.Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition[J]. Cancer biology & therapy, 2016, 17(11): 1117-1125.
[23] LIU Y P, DONG F X, CHAI X, et al.Role of autophagy in capsaicin-induced apoptosis in U251 glioma cells[J]. Cellular and molecular neurobiology, 2016, 36(5):737-743.
[24] VENIER N A, YAMAMOTO T, SUGAR L M, et al.Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model[J]. Prostate,2015,75(12):1300-1311.
[25] CHAKRABORTY S, ADHIKARY A, MAZMDAR M, et al.Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis[J]. PLoS one, 2014, 9(6): e99743.
[26] HWANG Y P, YUN H J, CHOI J H, et al.Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling[J]. Molecular nutrition & food research, 2011, 55(4):594-605.
[27] THOENNISSEN N H, O'KELLY J, Lu D, et al. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR/HER-2 pathway[J]. Oncogene, 2010, 29: 285-296.
[28] LEE S H,RICHARDSON R L,DASHWOOD R H,et al.Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells[J]. Journal of nutritional biochemistry,2012,23(6): 646-656.
[29] LEE G R, JANG S H, CHANG J K, et al.Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-κB signaling pathway[J]. Clinical ＆ experimental metastasis,2014,31(8): 897-907.
[30] BELTRAN J, GHOSH A K, BASU S.Immunotherapy of tumors with neuroimmune ligand capsaicin[J]. Journal of immunology, 2007, 178(5):3260-3264.
[31] SAYEED M A, BRACCI M, LUCARINI G, et al.Regulation of microRNA using promising dietary phytochemicals:Possible preventive and treatment option of malignant mesothelioma[J]. Biomedicine & pharmacotherapy, 2017, 94(1): 1197-1224.
[32] DE JONG P R, TAKAHASHI N, HARRIS A R, et al. Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis[J]. Journal of clinical investigation, 2014, 124(9):3793-3806.
[33] RONCONI G,LESSIANI G, SPINAS E, et al.ENOX2 (or tNOX):a new and old molecule with cancer activity involved in tumor prevention and therapy[J]. Journal of biological regulators and homeostatic agents, 2016, 30(3): 649-653.
[34] CHANG H C, CHEN S T, CHIEN S Y, et al.Capsaicin may induce breast cancer cell death through apoptosis inducing factor involving mitochondrial dysfunction[J]. Human & experimental toxicology, 2011, 30(10): 1657-1665.
[35] CHOI C H,JUNG Y K,OH S H.Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis[J]. Molecular pharmacology,2010,78(1):114-125.
[36] BLEY K, BOORMAN G, MOHAMAD B, et al.A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin[J]. Toxicologic pathology, 2012, 40(6): 847-873.
[37] LIN Y T, WANG H C, HSU Y C, et al.Capsaicin induces autophagy and apoptosis in human nasopharyngeal carcinoma cells by downregulating the PI3K /AKT /mTOR pathway[J]. International journal of molecular sciences,2017,18(7): e1343.
[38] SHIM Y, SONG J M.Quantum dot nanoprobe-based high-content monitoring of notch pathway inhibition of breast cancer stem cell by capsaicin[J]. Molecular and cellular probes,2015,29(6):376.
[39] SHARMA S K, VIJ A S, SHARMA M.Mechanisms and Clinical Uses of Capsaicin[J]. European journal of pharmacology, 2013, 720: 1-3.
[40] McCARTHY G M, McCARTHY D J. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hand[J]. Journal of rheumatology,1991,19:604-607.
[41] DERRY S, LLOYD R, MOORE R A, et al. Topical capsaicin for chronic neuropathic pain in adults[J]. Cochrane database of systematic reviews,2009,7(4): CD007393.
[42] WICK E C, HOGE S G, GRAHN S W, et al.Transiont receptor potential vanilloid l, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis[J]. American journal of physiology-gastrointestinal and liver physiology, 2006, 290(5): 959-969.
[43] CAVIEDES-BUCHELI J,AZUERO-HOLGUIN M M,MUNOZ H R. The effect of capsaicin on substance P expression in pulp tissue inflammation[J]. International endodontic journal,2005,38(1): 30-33.
[44] KIM M S, PARK C K, YEON K Y.Involvement of transient receptor potential vanilloid-1 in calcium current inhibition by capsaicin[J]. European journal of pharmacology,2006,530(1-2):144-151.
[45] BHAT B G, SRINIVASAN M R, CHANDRASEKHARA N.Influence of curcumin and capsaicin on the composition and secretion of bile in rats[J]. Journal of food science and technology-mysore, 1984, 21:225-227.
[46] PLATEL K, SRINIVASAN K.Influence of dietary spices or their active principles on pancreatic digestive enzymes in albino rats[J]. Nahrung, 2000, 44:42-46.
[47] PLATEL K, SRINIVASAN K.Studies on the influence of dietary spices on food transit time in experimental rats[J]. Nutrition research, 2001, 21:1309-1314.
[48] PRAKASH U N S, SRINIVASAN K. Fat digestion and absorption in spice pretreated rats[J]. Journal of the science of food and agriculture, 2012, 92:503-510.
[49] VEDA S, SRINIVASAN K.Influence of dietary spices on the in vivo absorption of ingested b-carotene in experimental rats[J]. British journal of nutrition, 2011, 105:1429-1438.
[50] BABOOTA RK, MURTAZA N, JAGTAP S, et al.Capsaicin induced transcriptional changes in hypothalamus and alterations in gut microbial count in high fat diet fed mice[J]. Journal of nutritional biochemistry, 2014, 25(9): 893-902.
[51] KANG C W B, KALIANNAN K, WANG X, et al. Gut microbiota mediates the protective effects of dietary Capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet[J]. mBio, 2017, 8(3): 470-417.
[52] KIM K M, KAWADA T, ISHIHARA K, et al.Increase in swimming endurance capacity of mice by Capsaicin-induced adrenal catecholamine secretion[J]. Bioscience, biotechnology, and biochemistry, 1997, 61(10): 1718-1723.
[53] 郭时印. 辣椒素抗疲劳作用及其机理研究[D] .长沙:中南大学,2009.
[54] KEMPAIAH R K, SRINIVASAN K.Influence of dietary curcumin, Capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats[J]. Annals of nutrition & metabolism, 2004, 48(5):314-320.
[55] BAILEY S,DAVIS J M,AHLBON E M.Brain serotonergic activity affect endurance performance in the rat[J]. International journal of sports medicine, 1993,(14): 330-333.
[56] JOO J I, KIM D H, CHOI J W, et al.Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet[J]. Journal of proteome research,2010,9(6):2977-2987.
[57] KIM J Y, LEE M S, JUNG S, et al.Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet[J]. International journal of nanomedicine, 2014, 9: 301-310.
[58] HSU C L, YEN G C.Effects of capsaicin on induction of apoptosis and inhibition of adipogenesisin 3T3-L1 cells[J]. Journal of agriculture and food chemistry, 2007, 55(5): 1730-1736.
[59] KANG J H, TSUYOSHI G, HAN I S, et al.Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet[J]. Obesity,2010,18(4):780-787.
[60] LEE G R, SHIN M K, YOON D J, et al.Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice[J]. Obesity,2013,21(1):115-122.
[61] KWON D Y, KIM Y S, RYU S Y, et al.Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats[J]. Journal of nutritional biochemistry,2013, 24(6):1078-1085.
[62] OKAMOTO H, TAKASAWA S.Recent advances in the Okamoto model: The CD38-Cyclic ADP-Ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-Cells[J]. Diabetes, 2002, 51(Suppl3):S462-S473.
[63] 梁晨. 韩盛玺. CAP 临床应用的研究进展[J]. 华西医学杂志,2008,23(2): 185-187.
[64] KAMAGATE A, DONG H H.FoxO1 integrates insulin signaling to VLDL production[J]. Cell cycle, 2008, 7(20):3162-3170.
[65] MITTELSTADT S W, NELSON R A, DAANEN J F, et al.Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1[J]. Blood coagul frinolysis, 2012, 23: 94-97.
[66] BROWNING K N, BABIC T, HOLMES G M, et al.A critical re-evaluation of the specificity of action of perivagal capsaicin[J]. Journal of physiology, 2013, 591(6):1563-1580.
[67] ZYGMUNT P M, PETERSSON J, ANDERSSON D A, et al.Vanilloid receptors on sensory nerves mediate the vasodilator action of anandainide[J]. Nature, 1999, 400: 452-457.
[68] YANG Z H, WANG X H, WANG H P, et al.Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen species production and mitochondrial depolarization[J]. Urology, 2010, 75: 735-741.
[69] 杨大春. 激活改善血管功能和预防高血压的机制研究[D]. 重庆: 第三军医大学,2009.
[70] ARNOLD W P,VAN DE KERKHOF P C. Topical capsaicin in pruritic psoriasis[J]. Journal of the American academy of dermatology, 1994, 31(1):135.
[71] ANAND P,BLEY K.Topical capsaicin for pain management: Therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch[J].British journal of anaesthesia, 2011, 107(4): 490-502.
[72] AHUJA KIRAN D K,ROBERTSON I K, GERAGHTY D P, et al. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism[J]. American journal of clinical nutrition, 2006(1):63.
[73] CHAIYASIT K,KHOVIDHUNKIT W,WITTAYALERTPANYA S.Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level[J]. Journal of the medical association of Thailand, 2009, 92(1):108-113.
[74] BELZA A, JESSEN A B.Bioactive food stimulants of sympathetic activity: Effect on 24-h energy expenditure and fat oxidation[J]. European journal of clinical nutrition, 2005, 59(6):733-741.