Abstract: The comprehensive score OD value of molding rate, moisture content, angle of repose and hygroscopic rate was taken as the investigation index. Using the single factor test and central composite design-response surface methodology, the molding process parameters such as the proportion of excipients and the density of liquid medicine of Masu Zhike granules were optimized. The results showed that the optimal molding process of Masu Zhike granules was the proportion of excipients（dextrin∶lactose） 0.17∶1, and the density of concentrated liquid medicine 1.25 g/cm³. Under this process, the total evaluation OD value was 0.657 7, which was equivalent to the predicted value （0.640 4）, and the relative error was -2.70%. The optimized molding process of Masu Zhike granules by central composite design-response surface methodology is stable and feasible, with a high molding rate, good fluidity, low moisture content and hygroscopic rate, and the results are reliable.

Key words: Masu Zhike granules, molding process, central composite design-response surface methodology