Abstract: In order to obtain the effective drugs for the treatment of Acrossocheilius hemispinus infected Ichthyopthirius multifillis, the therapeutic test of 8 aquaculture drugs with different density on the Acrossocheilius hemispinus artificial infected Ichthyopthirius multifillis was studied. The results showed that copper sulfate could accelerate the division and multiplication of Ichthyopthirius multifillis. Baicao antidote（natural plant carbon）had no effect on killing Ichthyopthirius multifillis vegetative body. When the formaldehyde solution was used alone, it had a certain killing effect on the vegetative body of Ichthyopthirius multifillis, but the treatment cycle was long and the survival rate of diseased fish was low. Benwenjing（dried ginger, pepper, apricot leaves） had no effect on killing the vegetative body of Ichthyopthirius multifillis, but it can improved the resistance of the diseased fish and reduced the mortality rate, so it should be used in conjunction with other insecticides. When the industrial salt（NaCl）concentration was between 3 000 and 5 000 mg/L, it could effectively remove the vegetative body of Ichthyopthirius multifillis off the diseased fish, and the cure rate of the diseased fish could reach （86.7±9.4）%. The Xiaoguajuesha（matrine, capsaicin）could accelerate the division and proliferation of Ichthyopthirius multifillis in the early stage, but it could effectively kill the larvae of Ichthyopthirius multifillis in the later stage. It was suitable to be used when the number of Ichthyopthirius multifillis was not large. When the treatment concentration of Yukangle（active calcium carbonate）was 4~6 mg/L, the insecticidal effect was obvious, and the cure rate of the diseased fish was（46.7±9.4）%~（60.0±0.0）%; When the treatment concentration of Bailingxiaoguajing（plant extracts）was 1.6~2.0 mg/L, the insecticidal effect was obvious, and the cure rate of the diseased fish was（80.0±0.0）%.

Key words: Acrossocheilius hemispinus, Ichthyopthirius multifillis, aquaculture drugs, therapeutic effect