Abstract: The protective effect and mechanism of Qingre Shengjigao on deep second degree scald wound in rats were studied. 100 SD rats were randomly divided into model group, burn cream group, high dose group of Qingre Shengjigao, and low dose group of Qingre Shengjigao. In the model group and the treatment group, the model of deep scald in the femoral part of the scald rat was made by the scald instrument, and the model of deep second degree scald was made by 8 s. Immediately giving medicine after injury, 1 times a day for 21 days, and taking samples at different times, the wound healing rate, water content, vascular endothelial growth factor（VEGF）content, hydroxyproline（Hyp）content, interleukin-1（IL-1） content, tumor necrosis factor beta（TNF-β）content were determined. The results showed that, Qingre Shengjigao has a good protective effect on deep two degree burn in rats, and its mechanism is related to the increase of VEGF and Hyp levels and the decrease of serum IL-1 and TNF- β levels.

Key words: Qingre Shengjigao, deep second degree scald, vascular endothelial growth factor（VEGF）, hydroxyproline（Hyp）, interleukin-1（IL-1）, tumor necrosis factor beta（TNF-β）;