Abstract: Graphene （GR）, as a kind of monatomic carbon nanomaterial, which has a unique two-dimensional conjugate planar structure and shows excellent chemical, mechanical, thermal and electrical properties. Graphene oxide （GO） is a precursor of graphene, which similar to the two-dimensional structure of graphene. GO surface containing a large number of oxygen-containing functional groups,resulting has a good water-soluble dispersion. The good conductivity of GR materials can be obtained by the chemical reduction method of GO. The graphene materials compositing with other functional materials would further improve the complex physical and chemical properties, such as dispersibility, workability and electrocatalytic activity. The fabricated high performance electrochemical biosensors by combining graphene （including GO） with carbon nanomaterials, metallic nanoparticles, metal oxides, non-metallic, polymers or other functional biomolecule materials to form the composite functional modified materials were reviewed. The nanostructural features of the composite material were explored and the application of its functional structure for improving the electrocatalytic and electrochemical selectivity of the sensor was also discussed.

Key words: graphene（GR）, graphene oxide（GO）, functional modification, electrochemistry, analysis performance