Abstract: In order to study the different organic fertilizer and fertilizer on the growth and quality of flue-cured tobacco in Sanming county of Fujian province, the effects of different methods of organic fertilizer and fertilizer application on the growth and quality of tobacco leaf production in Sanming county of Fujian province were studied by single factor randomized field experiment, using CB-1 as the test material. The results showed that the combination of organic fertilizer and fertilizer had no significant effect on the agronomic characters of tobacco during the agronomic period. Excessive application of organic fertilizer and too little application of tobacco special fertilizer（T5） would affect the opening of leaves; the combination of organic fertilizerand tobacco special fertilizer can significantly improve the disease resistance of tobacco plants; the effects of organic fertilizers and fertilizers on output and output were not significant（except T4 output value）; the combination of organic fertilizer and fertilizer can obviously reduce the content of nicotine, total nitrogen and chlorine in tobacco leaves, increase the content of potassium in tobacco leaves（except T1）, and improve the chemical coordination of tobacco leaves; improve the sensory quality of tobacco leaves（T3, T5）. In Sanming tobacco area of Fujian province, T3（tobacco special fertilizer 645 kg/hm²+rapeseed cake 375 kg/hm²+cow dung 1 500 kg/hm²） is suitable for fertilization.

Key words: organic fertilizer, fertilizer, flue-cured tobacco, yield and quality