The function of astragalus polysaccharides in hepatic steatosis of mice

doi:10.14088/j.cnki.issn0439-8114.2021.08.025

Abstract

Abstract: To study the preventive effect and mechanism of astragalus polysaccharides on diet induced hepatic steatosis of mice. The ICR mice were treated with high fat diet and 30% fructose water to building hepatic steatosis model. The mice of prevention groups were intragastric administration of 400 mg/kg astragalus polysaccharides at the same time of building model. After eight weeks, the liver histopathology, liver function, blood lipid and intestinal permeability were detected, and the expression of TLR4 and MyD88 protein in liver was analyzed by western blotting. Results showed that compared with the model group, astragalus polysaccharides caused the preventive group mice that the liver steatosis was reduced, the level of ALT, AST, ALP, TG, TC, GLU of serum were significantly reduced, the level of VDL was significantly increased, the intestinal permeability were decreased, and the expression level of TLR4 and MyD88 protein in liver was decreased. Astragalus polysaccharides can prevent hepatic steatosis, and its mechanism is related to improving intestinal barrier and regulating TLR4/MyD88 signaling pathway.

Key words: hepatic steatosis, astragalus polysaccharides, preventive effect, TLR4

CLC Number:

R282

WANG Chun-hua, SUN Xue-fang. The function of astragalus polysaccharides in hepatic steatosis of mice[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(8): 121-125.

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