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    Therapeutic effects of shikonin on complete Freund's adjuvant-induced rheumatoid arthritis mouse model
    HUANG Jun-xia,XIE You-yin, KONG De-yi, SHAO Li-lin, ZHANG Lei-fang
    HUBEI AGRICULTURAL SCIENCES    2023, 62 (1): 139-144.   DOI: 10.14088/j.cnki.issn0439-8114.2023.01.024
    Abstract279)      PDF (3077KB)(143)       Save
    To investigate the effect of shikonin (SHI) on rheumatoid arthritis (RA), ICR mice were randomly divided into 4 groups, including the normal group and three experimental groups (model group, positive drug group and SHI group). After 15 days of modeling, the drug treatment losted for 60 days. The positive drug group was given meloxicam 50 mg/(kg·d), the SHI group was given shikonin 2 mg/(kg·d), and the normal group and model group were given normal saline. The right ankle joint of the mice was separated, and the degree of synovial inflammation (grade 0-3), cartilage destruction (grade 0-4) and bone infiltration were evaluated. The thymus and spleen of mice were separated and thymus index and spleen index were calculated. Histopathological evaluation and some serum biochemical indexes (including inflammatory factors and antioxidant factors) were analyzed and determined. The results showed that shikonin could significantly improve the symptoms of joint redness in mice. The levels of nitric oxide (NO),tumor factor α (TNF-α),interleukin 1β (IL-1β) and interleukin 6 (IL-6),in the SHI group were significantly lower than those in the AA model group, the level of malondialdehyde (MDA) in serum as significantly lower than that in the AA model group, and the enzyme activity of superoxide dismutase (SOD) was significantly higher than that in the AA model group. The difference was statistically significaht(P<0.05 or P<0.01). Shikonin could relieve the inflammatory response of RA by reducing the level of inflammatory factors and improving the antioxidant capacity of the body.
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    Effects of total alkaloids from Alysicarpus vaginalis L. DC. on the collagen and cytokines of rat hepatic stellate cells
    TANG Yun-li, ZHENG Zuo-wen, GAN Cai-yu, LIANG Bing-jie, WEI Jian-hua, ZHANG Wen-tao, PENG Cheng
    HUBEI AGRICULTURAL SCIENCES    2023, 62 (1): 134-138.   DOI: 10.14088/j.cnki.issn0439-8114.2023.01.023
    Abstract271)      PDF (1729KB)(107)       Save
    The anti-fibrosis mechanism of total alkaloids of Alysicarpus vaginalis (AVTA) collagen and cytokines were investigated. MTT assay was used to detect the non-toxic concentration of AVTA inhibiting the proliferation of hepatic stellate cells. And the effect of AVTA(10.00,7.00,4.90 μg/mL) on the content of typeⅠcollagen (COLⅠ), type Ⅲ collagen (COL Ⅲ) and platelet-derived supernatant fluid growth factor (PDGF), tumor necrosis factor (TNF-α), insulin-like growth factor 1 (IGF 1) and Interleukin 6 (IL-6) were detected in T6 cells by ELISA. Results showed that the non-toxic concentration of AVTA inhibiting the proliferation of hepatic stellate cells was less than 13.72 μg/mL; Compared with the cells in the control group, the total alkaloid 10.00 μg/mL could inhibit the secretion of COL Ⅰ, COL Ⅲ, PDGF, TNF-α, IGF-1, IL-6 (P < 0.05 or P < 0.01).
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