糖基化在囊膜病毒感染中的作用机制

doi:10.14088/j.cnki.issn0439-8114.2021.15.002

摘要/Abstract

摘要： 糖类属于生物体内分布广泛且具有重要作用的有机化合物,在糖基转移酶的作用下共价连接在特定种类的蛋白质上形成糖苷键,该修饰过程即为糖基化。随着研究技术的发展,糖基化在病毒生物学中的功能被不断发掘,广泛应用在病毒诊断、疾病预防及治疗中,如抗病毒疫苗和药物的研制等。以病毒糖蛋白和宿主细胞糖蛋白为研究对象,讨论了糖基化修饰在囊膜病毒生物学中的功能与作用机制,并对前沿方向和实际应用进行了展望。

关键词: 糖基化修饰, 囊膜病毒, 免疫, 作用机制

Abstract: Saccharides are organic compounds that are widely distributed and have important functions. They are covalently linked to a particular kind of proteins by glycosyltransferases to form glycoproteins. This modification process named glycosylation. With the development of research technology, the function of glycosylation in virus biology has been continuously explored. Glycosylation is widely used in virus diagnosis, diseases prevention and treatment, such as the development of antiviral vaccines and drugs. In this article, the function and mechanism of glycosylation in the infection of enveloped virus were discussed with virus glycoproteins and host cell glycoproteins as research objects. The frontier direction and practical application were also prospected.

Key words: glycosylation, enveloped virus, immunity, mechanism

中图分类号:

Q291

武佳琪, 黄金海. 糖基化在囊膜病毒感染中的作用机制[J]. 湖北农业科学, 2021, 60(15): 11-15.

WU Jia-qi, HUANG Jin-hai. Mechanisms of glycosylation in enveloped virus infection[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(15): 11-15.

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