真菌SF-49356代谢产物的生物活性研究

doi:10.14088/j.cnki.issn0439-8114.2022.22.011

湖北农业科学 ›› 2022, Vol. 61 ›› Issue (22): 57-61.doi: 10.14088/j.cnki.issn0439-8114.2022.22.011

真菌SF-49356代谢产物的生物活性研究

刘曼莉, 舒芬, 张亚妮, 方伟, 石丽桥, 王开梅, 吴兆圆

湖北省生物农药工程研究中心, 武汉 430064

收稿日期:2022-09-16 出版日期:2022-11-25 发布日期:2023-01-11
通讯作者: 吴兆圆,女,副研究员,主要从事农药活性天然产物研究,（电子信箱）zhaoyuan.wu@nberc.com。
作者简介:刘曼莉（1982-）,女,广东惠州人,副研究员,博士,主要从事兽医学研究,（电话）15926216663（电子信箱）manli.liu@nberc.com
基金资助:
国家重点研发计划项目（2021YFD1800402）; 湖北省科技重大专项（2021ABA005）; 湖北省农业科技创新中心项目（2021-620-000-001-027）

The study of bioactivity of metabolites from a fungus SF-49356

LIU Man-li, SHU Fen, ZHANG Ya-ni, FANG Wei, SHI Li-qiao, WANG Kai-mei, WU Zhao-yuan

Hubei Biopesticide Engineering Research Centre,Wuhan 430064,China

Received:2022-09-16 Online:2022-11-25 Published:2023-01-11

摘要/Abstract

摘要： 从1株真菌SF-49356的代谢产物中经提取和制备高效液相色谱分离得到8个化合物,经紫外、质谱和天然产物词典（DNP）查询,鉴定为恩镰孢菌素类（Enniatins）化合物。抗菌活性筛选研究结果发现,该类化合物对革兰氏阳性菌金黄色葡萄球菌和猪链球菌有一定的抗菌活性,对猪伪狂犬病毒和猪繁殖与呼吸道综合征病毒无明显的抗病毒活性。

关键词: 天然产物, 真菌, 代谢产物, 恩镰孢菌素, 抗菌, 抗病毒

Abstract: Eight compounds were isolated from the metabolites of a fungus SF-49356 by high performance liquid chromatography（HPLC）, and identified as Enniatins by UV, MASS spectrometry and natural products dictionary （DNP）. The results of antibacterial activity screening showed that such compounds had certain antibacterial activity against Gram-positive bacteria including Staphylococcus aureus and Streptococcus suis, but had no obvious antiviral activity against porcine pseudorabies virus and porcine reproductive and respiratory syndrome virus.

Key words: natural products, fungus, metabolites, Enniatin, antibacterial, antiviral

中图分类号:

Q936

刘曼莉, 舒芬, 张亚妮, 方伟, 石丽桥, 王开梅, 吴兆圆. 真菌SF-49356代谢产物的生物活性研究[J]. 湖北农业科学, 2022, 61(22): 57-61.

LIU Man-li, SHU Fen, ZHANG Ya-ni, FANG Wei, SHI Li-qiao, WANG Kai-mei, WU Zhao-yuan. The study of bioactivity of metabolites from a fungus SF-49356[J]. HUBEI AGRICULTURAL SCIENCES, 2022, 61(22): 57-61.

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真菌SF-49356代谢产物的生物活性研究

The study of bioactivity of metabolites from a fungus SF-49356

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