关键词: 复方茯苓山药颗粒, 熵权TOPSIS, 正交试验, 薄层色谱法（TLC）

Abstract: Taking the relative density of clear paste, the ratio of clear paste and thinner, and the ratio of soluble starch and dextrin as the investigation factors, the L₉（3⁴） orthogonal test method was used to screen the best molding process Compound Fuling Shanyao Granules. The molding rate, moisture and resting angle were selected as indexes, and the best molding process was evaluated with the entropy weight TOPSIS method. The TLC method was used to identify Poria cocos, Chinese yam, Semen Coicis and Crataegus pinnatifida. The results showed that the TOPSIS model ranking results basically agreed with the optimal results obtained by the orthogonal test, indicating that the established model was successful. The TLC spots were clear, with good separation and no negative interference. The evaluation index of the entropy weight TOPSIS model was clearly defined, which was a practical, rapid and effective comprehensive evaluation method for the multi-objective decision analysis of selecting the best molding process of Compound Fuling Shanyao Granules. The TLC identification method was feasible, accurate and effective, which could be used for the quality control of Compound Fuling Shanyao Granules. This experiment could provide a basis for the follow-up study of this prescription.

Key words: Compound Fuling Shanyao Granules, entropy weight TOPSIS, orthogonal test, thin-layer chromatography （TLC）