病毒样颗粒疫苗的研究进展

doi:10.14088/j.cnki.issn0439-8114.2021.22.001

摘要/Abstract

摘要： 病毒样颗粒（Virus Like Particles,VLPs）疫苗通过表达病毒的结构蛋白组装形成与病毒相似的蛋白粒子结构,模拟病毒进入机体的过程,激活机体的免疫反应,从而达到抵御病毒的目的。VLPs疫苗凭借其高效安全的特性逐渐成为疫苗制备的热门选择。对VLPs疫苗的分类、优势、表达系统、组装纯化、鉴定方法、免疫通路、疫苗修饰等方面的研究进行综述,以期对VLPs疫苗的研究提供参考。

关键词: 病毒样颗粒（VLPs）, 疫苗, 修饰, 表达系统, 免疫

Abstract: Virus like particles（VLPs） vaccine can form a protein particle structure similar to the virus by expressing the structural protein assembly of the virus, simulate the process of the virus entering the body, activate the immune response of the body, so as to achieve the purpose of resisting the virus. VLPs vaccine has become a popular choice for vaccine preparation because of its high efficiency and safety. Classification of VLPs vaccines, advantages, expression systems, purification assembly, identification methods, immune pathways, modified vaccine and other aspects were reviewed in order to provide reference for the study of VLPs vaccines.

Key words: virus like particles, vaccine, modification, expression system, immunity

中图分类号:

S961.6

谭坤, 张丽琳. 病毒样颗粒疫苗的研究进展[J]. 湖北农业科学, 2021, 60(22): 5-10.

TAN Kun, ZHANG Li-lin. Research progress of virus like particles vaccine[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(22): 5-10.

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