Study on mechanism of Arisaema consanguineum anti-cancer based on network pharmacology

doi:10.14088/j.cnki.issn0439-8114.2020.23.025

Abstract

Abstract: This study used the method of network pharmacology to study the anticancer mechanism of Arisaema consanguineum.The active components and targets of Arisaema consanguineum were searched using the TCMSP database,and these targets were uniformly named using the Uniprot database.Cytoscape 3.7.1 was used to establish a compound-anti-cancer target visualization network map,and the STRING database was used to construct the PPI network.Enrichment pathway analysis was performed using the DAVID website and the ImageGP database.Bioprocess analysis was performed using ClueGo software.The results showed that,a total of 42 anti-cancer active components and 65 anti-cancer targets were collected.The main anticancer active substances of Arisaema consanguineum include terpineol and linoleic acid.Important anti-cancer targets are ADH1B,ADH1C and the like.Arisaema consanguineum can show the multi-component,multi-target and multi-pathway anticancer function by by regulating TNF signaling pathways and p53 signaling pathways through biological processes such as participation in neuroactive ligand-receptor interactions and cancer processes.

Key words: network pharmacology, Arisaema consanguineum, anticancer mechanism

CLC Number:

HAO Ai-ping, WU Qi-kang, GUO Hui-yan, XUE Ju-kun, WEI Ji-cheng, REN Ru-yi. Study on mechanism of Arisaema consanguineum anti-cancer based on network pharmacology[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(23): 110-115.

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