Mechanism of Panax notoginseng in the treatment of arthritis based on network pharmacology

doi:10.14088/j.cnki.issn0439-8114.2021.02.022

Abstract

Abstract: The main effective components of Panax notoginseng were retrieved by TCMSP database under the condition of OB > 30% and DL > 0.18; The target of active ingredients was extracted by Drugbank and UniProt database, and the related targets of arthritis were screened by GeneCards and OMIM database;making Veen map of related targets of Panax notoginseng in the treatment of arthritis; Then, we use the software of Cytoscape 3.6.0 and the database of String to draw PPI network diagram and the network control diagram of Panax notoginseng, active ingredient, target gene and arthritis respectively; Finally, R language is used as a tool to screen key targets and analyze their biological processes and important signaling pathways, to study the mechanism of Panax notoginseng in the treatment of arthritis by network pharmacology. The results showed that eight main components of Panax notoginseng were retrieved, including β-sitosterol, stigmasterol and ginsenoside rh2; 131 related targets of Panax notoginseng in the treatment of arthritis; The key targets of Panax notoginseng are mainly involved in protein heterodimerization activity, DNA-binding transcription activator activity,RNA polymerase II-specific,cytokine receptor binding and other biological processes; It is necessary to play a role in the treatment of arthritis through AGE-RAGE signaling pathway in diabetic complication,fluid shear stress and atherosclerosis, Hepatitis B and other important signal pathways.

Key words: Panax notoginseng, arthritis, network pharmacology

CLC Number:

R282

HAN Qian, CHEN Yong, WANG Jing-jing, WEI Jiang-cun, HUANG Zhou-yan, CHEN Liang-ni. Mechanism of Panax notoginseng in the treatment of arthritis based on network pharmacology[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(2): 109-115.

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