Research progress on the function of ubiquitination modification in DNA damage repair

doi:10.14088/j.cnki.issn0439-8114.2020.24.003

Abstract

Abstract: DNA damage can cause instability of genome, therefore, which makes the normal cells cancerous. Therefore, the DNA damage repair is essential for genome stability and preventing cells from becoming cancerous. There are numerous DNA damage repair factors participate in DNA damage repair response in the cells, some of them will be modificated when they functionating in DNA damage repair response, one of the most significant modifications is ubiquitination modification. In this review, we will shed light on the research progress of ubiquitination modification in the DNA damage repair response,and to provide theoretical basis for the treatment and basic research of related diseases correspondingly.

Key words: DNA damage, DNA damage repair, mutations, canceration, ubiquitination

CLC Number:

QIN Xiao-bing. Research progress on the function of ubiquitination modification in DNA damage repair[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(24): 16-20.

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