Protective effect of baicalin on porcine extra-intestinal pathogenic Escherichia coli in vivo

doi:10.14088/j.cnki.issn0439-8114.2023.05.022

Abstract

Abstract: To explore the protective effect of baicalin on mice infected with porcine extraintestinal pathogenic Escherichia coli, the survival rate assay and colonization assay of mice were selected to evaluate the protective effect of baicalin. The clinical feature, survival rate, tissue bacterial load and pathological changes of mice in the infected group and baicalin treatment group were compared. The results showed that the mental state of mice treated by baicalin was better than that of the mice infected by PCN033. The survival rate of the baicalin treatment group was improved compared with that of the infection group. Bacterial counts in heart, liver, spleen and kidney of mice treated with baicalin were significantly reduced compared with those of mice infected with PCN033 （P<0.01）.

Key words: baicalin, porcine extraintestinal pathogenic Escherichia coli, mice, survival rate, colonization

CLC Number:

R378
R284

REN Ming-xing, XIAO Yong, FU Shu-lin, ZONG Bing-bing, QIU Yin-sheng. Protective effect of baicalin on porcine extra-intestinal pathogenic Escherichia coli in vivo[J]. HUBEI AGRICULTURAL SCIENCES, 2023, 62(5): 124-128.

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