Research progress on Vibrio bacteriophage endolysin and depolymerase

doi:10.14088/j.cnki.issn0439-8114.2025.08.028

Abstract

Abstract: The use of antibiotics is primary method of combating bacterial pathogens, which has led to issues such as antibiotic residues, environmental pollution, and the increase in multidrug-resistant bacteria, thereby escalating the difficulty in infection control. As natural predators of bacteria, bacteriophages offered a promising alternative with substantial potential. Bacteriophage endolysin was a cell wall peptidoglycan hydrolase or transglycosidase, and depolymerases degraded extracellular matrix polysaccharides, which exhibited high efficacy and specificity in lysing bacterial cells. This review summarized recent advances in endolysin and depolymerase from Vibrio bacteriophages and their applications in pathogen control. The aim was to provide insights and references for researchers developing novel, eco-friendly antibacterial agents.

Key words: bacteriophage, endolysin, depolymerase, Vibrio sp.

CLC Number:

Q939.48

HAN Wen-xin, YANG Rui-bing, SUN Xiao-wen, WANG Li-li, LI Xiao-yu, CONG Cong. Research progress on Vibrio bacteriophage endolysin and depolymerase[J]. HUBEI AGRICULTURAL SCIENCES, 2025, 64(8): 183-188.

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