Investigation of the antioxidant and lipid-lowering activities of lotus alkaloids and their antibacterial properties against plant pathogens

doi:10.14088/j.cnki.issn0439-8114.2025.11.011

Abstract

Abstract: A systematic comparative study was conducted to investigate the compositional differences of alkaloids in lotus leaves and lotus plumules, along with their respective antioxidant, lipid-lowering, and antibacterial properties. The analysis revealed a distinct compositional profile: Alkaloids in lotus leaves were predominantly of the aporphine-type, with nuciferine(lotus leaf alkaloid) being the most abundant, while bisbenzylisoquinoline alkaloids were predominant in lotus plumules, with neferine(methyl lotus plumule alkaloid) having the highest content. Functionally, the total alkaloids from lotus leaves exhibited superior antioxidant and lipid-lowering activities, demonstrating stronger DPPH radical scavenging capacity and pancreatic lipase inhibition both in a concentration-dependent manner compared to the total alkaloids from plumule. In antibacterial assays, the leaf alkaloids also showed more potent and sustained efficacy against Pseudomonas syringae pv. tomato, DC3000 and Alternaria nelumbii. Stability assessments, however, indicated that the antibacterial activity of the leaf alkaloids was susceptible to high temperatures, in contrast to the higher thermal stability observed for the plumule alkaloids. Furthermore, the presence of metal ions (Ca²⁺ and Mg²⁺) significantly suppressed the antibacterial activity of both alkaloid types, with a more pronounced inhibitory effect on the alkaloids derived from lotus plumules.

Key words: lotus(Nelumbo nucifera), alkaloids, antioxidant, lipid-lowering, antimicrobial

CLC Number:

WANG Wen-hao, ZENG Yu-ting, YANG Zi-jian, LI Jing. Investigation of the antioxidant and lipid-lowering activities of lotus alkaloids and their antibacterial properties against plant pathogens[J]. HUBEI AGRICULTURAL SCIENCES, 2025, 64(11): 86-95.

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