Abstract: A rat model of spleen deficiency was established by the method of purging the bitter cold from rhubarb, the regulating effect of three different processed products of Radix codonopsis on the intestinal flora of rats with spleen deficiency were observed. The normal group, model group, Radix codonopsis group, Mi Radix codonopsis group, and honey Radix codonopsis group were set up,and continuously give corresponding drugs to detect the changes in the number of intestinal flora before and after the experiment. Results showed that the number of intestinal flora of rats in the normal group and the model group did not change significantly; after the rats of the Mi Radix codonopsis group were successfully modeled, the number of bifidobacteria and lactobacilli in the intestine increased, and the number of Escherichia coli and staphylococcus decreased; Radix codonopsis after the rats in the raw product group and the Radix codonopsis group were administered, the number of bifidobacteria and lactobacilli in the intestinal tract increased, and the number of Escherichia coli and staphylococcus decreased compared with the number of Radix codonopsis group, returning to near normal levels. The three different processed products of Radix codonopsis have obvious regulating effect on the intestinal flora of rats with spleen deficiency, and the regulating effect of Radix codonopsis on spleen deficiency rats was better than that of raw Radix codonopsis and honey Radix codonopsis.

Key words: Radix codonopsis, processed products, intestinal flora, spleen-deficiency model rats