Synthesis of 4-Fluorobenzylamines and Its Antibacterial Activity Against Erwinia carotorora

doi:10.14088/j.cnki.issn0439-8114.2018.23.022

Abstract

Abstract: Starting from 4-fluorobenzylamine and 20 types of acyl chlorides,11 fatty（3A01~3A11） and 9 aromatic（3B01~3B09） derivatives of fluorobenzylamide were synthesized via N-acylation reaction,and their structures were characterized by MS and ¹H NMR spectroscopic analysis. The antibacterial activities of the title compounds against Erwinia carotorora were evaluated by paper disc method. The results of bio-assay showed that 3A01,3A07,3B03,and 3B09 had strong inhibitory against Erwinia carotorora（20 μg of tested compound per disc）,and the diameters of the inhibitory zone of them were 17,15,15 and 13 mm,respectively.

Key words: 4-fluorobenzylamines, synthesis, Erwinia carotorora, antibacterial activity

CLC Number:

TQ460.3
S432

HUANG Jian-dong, QIAN Yong, YANG Shi-jie, WANG Peng-jun, FENG Bao-jun, XIE Tian-pei. Synthesis of 4-Fluorobenzylamines and Its Antibacterial Activity Against Erwinia carotorora[J]. HUBEI AGRICULTURAL SCIENCES, 2018, 57(23): 94-97.

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