Identification of secondary metabolites from the fungus Penicillium sp.1502 and their bioactivities

doi:10.14088/j.cnki.issn0439-8114.2022.20.012

Abstract

Abstract: The secondary metabolites and their bioactivities produced by Penicillium sp.1502 were investigated. Six compounds were isolated from ethyl acetate extract of the fungus fermentation broth by silica gel column chromatography and preparative HPLC, and their structures were identified as methyl asterric acid（1）, methyl 3,5-dichloroasterric acid（2）, sulochrin（3）, monochlorsulochrin（4）, dihydrogendin（5） and penipurdin A（6） by LC-MS and NMR. Compound 1 to compound 6 were further evaluated for antimicrobial and antifungal activities, and insecticidal activities against Aphis craccivora. The results showed that compound 3 to compound 5 showed weak activities against Streptococcus suis with MIC of 200 μg/mL, respectively, while compound 1 to compound 6 exhibited no obvious bioactivities against the six tested plant-pathogenic fungi and Aphis craccivora.

Key words: Penicillium sp., secondary metabolites, bioactivities

CLC Number:

S482.4

ZHANG Ya-ni, LIU Man-li, ZHANG Zhi-gang, WAN Zhong-yi, WU Zhao-yuan, WANG Kai-mei, FANG Wei. Identification of secondary metabolites from the fungus Penicillium sp.1502 and their bioactivities[J]. HUBEI AGRICULTURAL SCIENCES, 2022, 61(20): 64-68.

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