miRNA对畜禽脂肪沉积的影响及在遗传育种中的应用

doi:10.14088/j.cnki.issn0439-8114.2020.13.003

湖北农业科学 ›› 2020, Vol. 59 ›› Issue (13): 14-18.doi: 10.14088/j.cnki.issn0439-8114.2020.13.003

miRNA对畜禽脂肪沉积的影响及在遗传育种中的应用

李心语^1a, 安清明², 王大会², 贺花^1b, 冯紫婷^1a, 文逸凡^1a, 雷初朝^1a, 陈宏^1a, 黄永震^1a

1.西北农林科技大学,a. 动物科技学院; b. 动物医学院, 陕西杨凌 712100;
2.铜仁学院农林工程与规划学院,贵州铜仁 554300

收稿日期:2019-11-08 出版日期:2020-07-10 发布日期:2020-09-03
通讯作者: 黄永震(1982-),男,河南南阳人,副教授,博士,硕士生导师,主要从事动物遗传与育种研究,(电子信箱)hyzsci@nwafu.edu.cn。
作者简介:李心语(1999-),女,陕西西安人,在读本科生,研究方向为动物遗传与育种, (电话)15029219212(电子信箱)lixinyu1502@126.com。
基金资助:
国家自然科学基金青年科学基金项目(31601926); 铜仁市科技计划项目(铜仁科研[2016]18号-5); 贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字2017-089); 贵州省科技计划项目(黔科合支撑2018-1161; 2018-2277); 国家肉牛牦牛产业技术体系专项(CARS- -37); 西北农林科技大学2019年大学生创新创业训练计划项目(X201910712169)

The effect of microRNAs on fat deposition in livestock and poultry and its application in genetics and breeding

LI Xin-yu^1a, AN Qing-ming², WANG Da-hui², HE Hua^1b, FENG Zi-ting^1a, WEN Yi-fan^1a, LEI Chu-zhao^1a, CHEN Hong^1a, HUANG Yong-zhen^1a

1a. College of Animal Science and Technology; 1b. College of Veterinary Medicine,Northwest Agriculture and Forestry University,Yangling 712100, Shaanxi, China;
2. College of Agriculture and Forestry Engineering, Tongren Unviersity, Tongren 554300, Guizhou, China

Received:2019-11-08 Online:2020-07-10 Published:2020-09-03

摘要/Abstract

摘要： 畜禽基因与其性状的关联研究较为广泛,具有编码效应的DNA和RNA对性状有重要影响,非编码RNA中的miRNA可以通过影响mRNA的翻译而对畜禽的性状产生特定影响。总结了miRNA在畜禽脂肪代谢中的研究进展,以期为今后进一步研究畜禽脂肪组织中miRNA的表达和功能提供参考。

关键词: miRNA, 脂肪沉积, 畜禽, 育种

Abstract: The association between genes and characters of livestock and poultry was widely studied. DNA and RNA with coding effect have important effects on traits. In addition, miRNA in non-coding RNA can have a specific effect on livestock and poultry traits by affecting the translation of mRNA. The research of miRNA in fat metabolism of livestock and poultry was summarized, in order to provide reference for further research on the description and functions of miRNA in fat tissue of livestock and poultry.

Key words: miRNA, fat deposition, livestock and poultry, breeding

中图分类号:

Q343.1⁺5

李心语, 安清明, 王大会, 贺花, 冯紫婷, 文逸凡, 雷初朝, 陈宏, 黄永震. miRNA对畜禽脂肪沉积的影响及在遗传育种中的应用[J]. 湖北农业科学, 2020, 59(13): 14-18.

LI Xin-yu, AN Qing-ming, WANG Da-hui, HE Hua, FENG Zi-ting, WEN Yi-fan, LEI Chu-zhao, CHEN Hong, HUANG Yong-zhen. The effect of microRNAs on fat deposition in livestock and poultry and its application in genetics and breeding[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(13): 14-18.

参考文献

[1] LI X H,JIANG P,YU H B,et al.MiR-21-3p targets Elovl5 and regulates triglyceride production in mammary epithelial cells of cow[J]. DNA and cell biology,2019,38(4):352-357.
[2] ZHANG Y Y,WANG Y N,WANG H B,et al.MicroRNA-224 impairs adipogenic differentiation of bovine preadipocytes by targeting LPL[J]. Molecular and cellular probes,2019,44:29-36.
[3] ZHANG M Q, GAO J L, LIAO X D, et al.MiR-454 regulates triglyceride synthesis in bovine mammary epithelial cells by targeting PPAR-γ[J]. Gene,2018,691:1-7.
[4] MA X Y, WEI D W, CHENG G, et al.Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle[J]. Molecular and cellular probes,2018,42:10-17.
[5] 邵静,夏广军. 牛肌内脂肪沉积相关miRNA研究进展[J]. 黑龙江畜牧兽医,2018(11):84-87.
[6] TANG K Q, WANG Y N, ZAN L S, et al.MiR-27a controls triacylglycerol synthesis in bovine mammary epithelial cells by targeting peroxisome proliferator-activated receptor gamma[J]. Journal of dairy science,2017,100(5):4102-4112.
[7] WANG H Y, XIAO S H, WANG M, et al.In silico identification of conserved microRNAs and their targets in bovine fat tissue[J]. Gene,2015,559(2):119-128.
[8] SUN J J, ZHOU Y, CAI H F, et al.Discovery of novel and differentially expressed microRNAs between fetal and adult backfat in cattle[J]. PloS one,2014,9(2): e90244.
[9] ZHOU G X, WANG X L, YUAN C, et al. Integrating miRNA and mRNA expression profiling uncovers miRNAs underlying fat deposition in sheep[J]. BioMed research international,https://doi.org/10.1155/2017/1857580.
[10] PAN Y,JING J,QIAO L,et al.MiRNA-seq reveals that miR-124-3p inhibits adipogenic differentiation of the stromal vascular fraction in sheep via targeting C/EBP[J]. Domestic animal endocrinology,2018, 65:17-23.
[11] BYRNE K, COLGRAVE M L, VUOCOLO T, et al.The imprinted retrotransposon-like gene PEG11(RTL1) is expressed as a full-length protein in skeletal muscle from Callipyge sheep[J]. PLoS One,2010,5(1): e8638.
[12] ZHAO W, YANG H L, LI J T, et al.MiR-183 promotes preadipocyte differentiation by suppressing Smad4 in goats[J]. Gene,2018,158(6) :158-164.
[13] MA L A,QIU H L,CHEN Z,et al.MiR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PCG-1beta[J]. Journal of animal science and biotechnology,2018,9(4):868-877.
[14] CHEN Z, QIU H L, MA L A, et al.MiR-30e-5p and miR-15a synergistically regulate fatty acid metabolism in goat mammary epithelial cells via LRP6 and YAP1[J]. International journal of molecular sciences,2016,17(11): e1909.
[15] WANG H, SHI H P, LUO J, et al.MiR‐145 regulates lipogenesis in goat mammary cells via targeting INSIG1 and epigenetic regulation of lipid‐related genes[J]. Journal of cellular physiology,2017,232(5):1030-1040.
[16] WANG K J,LI W T,BAI Y,et al.ssc-miR-7134-3p regulates fat accumulation in castrated male pigs by targeting MARK4 gene[J]. International journal of biological sciences,2017,13(2):189-197.
[17] LI Y Y, LI X C, SUN W K, et al.Comparison of liver microRNA transcriptomes of Tibetan and Yorkshire pigs by deep sequencing[J]. Gene,2016, 577(2):244-50.
[18] TANIGUCHI M, NAKAJIMA I, CHIKUNI K, et al.MicroRNA-33bdownregulates the differentiation and development of porcine preadipocytes[J]. Molecular biology reports,2014,41(2):1081-1090.
[19] MENTZEL C M,ANTHON C,JACOBSEN M J, et al.Gender and obesity specific microRNA expression in adipose tissue from lean and obese pigs[J]. PLoS One, 2015, 10(7): e0131650.
[20] LIU S Y,SUN G J,YUAN B, et al.miR‐375 negatively regulates porcine preadipocyte differentiation by targeting BMPR2[J]. FEBS Letters,2016, 590(10): 1417-1427.
[21] JI H L, SONG C C, LI Y F, et al.MiR-125a inhibits porcine preadipocytes differentiation by targeting ERRa[J]. Molecular and cellular biochemistry,2014, 395(1-2):155-165.
[22] DU J J, XU Y, ZHANG P W, et al.MicroRNA-125a-5p affects adipocytes proliferation, differentiation and fatty acid composition of porcine intramuscular fat[J]. International journal of molecular sciences,2018,19(2): e501.
[23] LIU L Q, QIAN K, WANG C L.Discovery of porcine mi RNA-196a/b may influence porcine adipogenesis in longissimus dorsi muscle by mi RNA sequencing[J]. Animal genetics,2017,48(2):175-181.
[24] 邵芳, 王星果, 郁建锋,等. miR-33靶向调控鸡CHPT1基因表达[J]. 农业生物技术学报,2019,27(1):118-126.
[25] LIU L,WANG Q,WANG Q,et al.Role of miR29c in goose fatty liver is mediated by its target genes that are involved in energy homeostasis and cell growth[J]. BMC veterinary research,2018, 14(1):325.
[26] ZHANG M, LI D H, LI F, et al.Integrated analysis of miRNA and genes associated with meat quality reveals that Gga-MiR-140-5p affects intramuscular fat deposition in chickens[J]. Cellular physiology and biochemistry ,2018,46(6):2421-2433.
[27] FU S Y, ZHAO Y L, LI Y F, et al.Characterization of miRNA transcriptome profiles related to breast muscle development and intramuscular fat deposition in chickens[J]. Journal of cellular biochemistry,2018,119(8):7063-7079.

miRNA对畜禽脂肪沉积的影响及在遗传育种中的应用

The effect of microRNAs on fat deposition in livestock and poultry and its application in genetics and breeding

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