Progress in immunological effects and application of CpG ODN nano adjuvant

doi:10.14088/j.cnki.issn0439-8114.2020.13.002

Abstract

Abstract: CpG ODN is a synthetic DNA sequence with non-specific immunostimulation which simulates the response process of bacterial DNA in vivo, inducing cellular and humoral immunity. CpG ODN has shown great potential as a novel immunopotentiator in veterinary clinical applications, and has attracted much attention in the fields of immunology, pharmacology and pharmacodynamics. However, CpG ODN is unstable and easily digested by nucleases, which are negatively charged and do not easily bind to the cell surface. Therefore, how to efficiently transfer CpG ODN and effectively ingest it becomes a new challenge. The study of nano-transmission system has achieved significant efficacy for CpG ODN alone or in combination with vaccine immunization, and broadened the thinking for improving the application of CpG ODN in vaccine research. The mechanism of action, immunological activity, safety and clinical application of CpG ODN nanoadjuvant were summarized, and future research directions in this field was prospected, to provide useful reference for follow-up work.

Key words: CpG ODN, nano adjuvant, mechanism of action, immunological activity, safety

CLC Number:

Q291

WANG Zheng-fan, WAN Zeng-pei, GAO Xiao-peng, YING Bi-yun, XIANG Rui, LI Yi-yun, PANG Xuan-fei, LI Zhong-sheng, BAI Ai-quan. Progress in immunological effects and application of CpG ODN nano adjuvant[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(13): 10-13.

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