Study on functional components and targets of walnut in prevention and treatment of Alzheimer's disease based on network pharmacology

doi:10.14088/j.cnki.issn0439-8114.2021.24.034

Abstract

Abstract: The mechanism of walnut（Juglans regia L.） in prevention and treatment of Alzheimer's disease（AD） was explored based on network pharmacology. The active components and potential targets of walnut were obtained by TCMSP database and literature mining. The prediction and screening of AD related genes were performed using databases such as OMIM; Cytoscape 3.7.2 software was used to construct a “drug-active component-disease-target” network to formation of the interactive relationship of walnuts toprevent AD components and target, and analysis of GO function and KEGG pathway enrichment. The results showed that 29 walnut active ingredients were screened, 17 of which had 159 AD-related targets. PTGS1/2, RXRA, RELA, MAOB and NOS3 may be the key targets of AD. The main signal pathways were AGE-RAGE signaling pathway, atherosclerosis, PI3K-Akt signaling pathway, IL-17 signaling pathway and HIF-1 signaling pathway. Walnut can prevent and control AD through multi-component, multi-target, and multi-pathway. The components with the most targets are quercetin, oleic acid, and ellagic acid; the targets affected by the most compounds are prostaglandin G/H synthase, retinoic acid receptor RXR-alpha, transcription factor p65, amine oxidase [flavin-containing] B and nitric oxide synthase.

Key words: walnut（Juglans regia L.）, Alzheimer's disease, internet pharmacology, mechanism of action

CLC Number:

S664.1

XU Cheng-mei, CHEN Dan, XU Dong-yue, ZHAO-QING Yu-jing, LIN Yu-ping, ZHAO Sheng-lan. Study on functional components and targets of walnut in prevention and treatment of Alzheimer's disease based on network pharmacology[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(24): 151-159.

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