Study on mechanism of heat-clearing and detoxifying efficacy of Flos chrysanthemi based on systems pharmacology

doi:10.14088/j.cnki.issn0439-8114.2021.10.028

Abstract

Abstract: Based on the method of systems pharmacology, the mechanism of heat-clearing and detoxifying efficacy of Flos chrysanthemi was explored. The TCMSP, Drugbank, STRING, DAVID, BIOGPS and others online databases were used for selecting the core compounds, building network, selecting the core targets, analyzing the signal pathway and meridian channel tropism. The heat-clearing and detoxifying efficacy of Flos chrysanthemi mainly through 21 compounds, including quercetin, kaempferol, luteolin and Naringenin, acting on 255 targets. The core targets of Flos chrysanthemi involved JUN, TP53, AKT1, MAPK3, MAPK1, RELA and TNF. GO function enrichment analysis yielded 146 GO entries. KEGG enrichment analysis showed that targets of Flos chrysanthemi mainly act on inflammatory and immune related signaling pathways. Through the analysis of meridian channel tropism of targets, the core targets of Flos chrysanthemi was mainly located in the lung, smooth muscle and liver. The Flos chrysanthemi may play the role of heat-clearing and detoxifying efficacy through the pharmacological function of quercetin, kaempferol, luteolin and other core compounds in lung, liver and other organs, and its mechanism was related to the regulation of inflammation related signal pathway through AKT1, TNF and other targets to play an anti-inflammatory role.

Key words: Flos chrysanthemi, systems pharmacology, heat-clearing and detoxifying efficacy, mechanism of action

CLC Number:

R966

WANG Chun-hua, QU Xue-jia, KONG Ling-yu, SUN Xue-fang. Study on mechanism of heat-clearing and detoxifying efficacy of Flos chrysanthemi based on systems pharmacology[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(10): 137-141.

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