Abstract: To evaluate the effects of Shaohuang granules on psoriasis mice, a imiquimod-induced psoriasis model was constructed and used to observe the influence of Shaohuang granules on the pathological changes, epidermal thickness, the expression of PCNA in psoriatic lesions. The effects of Shaohuang granules on the mitosis of vaginal epithelial cells in estrogen period and the granular layer of mice tail epidermis were also observed. The results showed that Shaohuang granules could obviously decreased the skin thickness of psoriasis mice （P<0.05）. 10 g/kg and 5 g/kg dose of Shaohuang granules could improve the mice skin lesions and reduce the PCNA expressions significantly. 10 g/kg dose of Shaohuang granules could obviously inhibit the mitosis of mice vaginal epithelium in estrogen period and had distinct promotion effect on the granular layer formation of mice tail epidermis. It indicated that Shaohuang granules are effective on treating psoriasis. It can decrease the skin thickness and improve skin lesion by affecting the epidermal parakeratosis and epidermal over-proliferation. It also can inhibit the mitosis of vaginal epithelial cells and promote the epidermal granules formation of mice tail.

Key words: Shaohuang granules, psoriasis, mouse model