Anti-inflammatory activity of different polar fractions from Jasminum nervosum Lour

doi:10.14088/j.cnki.issn0439-8114.2026.02.021

Abstract

Abstract: Models of xylene-induced ear edema, carrageenan-induced paw edema, and cotton pellet-induced granuloma in mice were established to investigate the effects of petroleum ether, ethyl acetate, n-butanol, and aqueous fractions of Jasminum nervosum on acute and chronic inflammation. Serum levels of inflammatory factors were measured, and histopathological changes were observed. Acute toxicity tests indicated that the ethanol extract of Jasminum nervosum exhibited no significant toxicity. In anti-inflammatory assays, compared with the model group, the dexamethasone group and the high-dose groups of the petroleum ether and ethyl acetate fractions significantly inhibited mouse ear edema (P<0.01), and the low-dose ethyl acetate fraction group also showed significant inhibition (P<0.05). In the paw edema model, the high- and medium-dose ethyl acetate fraction groups significantly suppressed edema (P<0.01, P<0.05). In the granuloma model, the high-dose ethyl acetate fraction group significantly reduced granulation tissue hyperplasia (P<0.01). Additionally, all dose groups of the ethyl acetate fraction significantly lowered serum levels of NO, iNOS, IL-6, IL-1β, and COX-2 (P<0.01), and the high-dose group alleviated inflammatory cell infiltration in paw tissue. Different polar fractions of Jasminum nervosum exhibited anti-inflammatory effects, with the ethyl acetate fraction demonstrating the most significant inhibition of both acute and chronic inflammation. Its mechanism was likely related to the regulation of inflammatory factors such as NO, iNOS, IL-6, IL-1β, and COX-2.

Key words: Jasminum nervosum Lour., anti-inflammatory, ethyl acetate fraction, inflammatory mediators, mouse

CLC Number:

R965.1

GAO Mei-fei, ZHOU Jia-jing, YUAN Cai-ying, PAN Xiao-fang, HUO Li-ni, CHEN Rui. Anti-inflammatory activity of different polar fractions from Jasminum nervosum Lour[J]. HUBEI AGRICULTURAL SCIENCES, 2026, 65(2): 143-147.

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