Study on the mechanism of flavonoids from three kinds of alpinia herbs in rats with gastric ulcer cold syndrome

doi:10.14088/j.cnki.issn0439-8114.2022.15.027

Abstract

Abstract: The effects of the flavonoids from Alpinia officinarum Hance, Alpinia galanga （L.） Willd., seeds of Alpinia galanga （L.） Willd. on SOD activity and contents of MDA, bFGF and PDGF in gastric tissue of rats were observed to explore the mechanism of action on gastric mucosal repair in rats with gastric ulcer cold syndrome. The rat model of gastric ulcer cold syndrome was prepared by irrigation of cold water decoction of rhizoma anemarrhenae and 15% glacial acetic acid. The activity of SOD and the contents of MDA, bFGF and PDGF in gastric tissue of rats were observed with gingerol as the positive control. The results showed that, the content of MDA in the gastric tissues of rats in the high and low dose Alpinia officinarum Hance group, the high-dose Alpinia galanga （L.） Willd. group and the high-dose seeds of Alpinia galanga （L.） Willd. group showed a significant or extremely signficant decrease （P<0.01 or P<0.05）. SOD activity in gastric tissues of rats in the high-dose group of Alpinia officinarum Hance, Alpinia galanga （L.） Willd. and seeds of Alpinia galanga （L.） Willd. showed a significant or extremely signficant increase （P<0.01 or P<0.05）. The content of bFGF in gastric tissues of rats increased significantly in the high and low dose Alpinia officinarum Hance group, the high-dose group of Alpinia galanga （L.） Willd. and seeds of Alpinia galanga （L.） Willd. （P<0.01）. The content of PDGF in gastric tissues of rats in the high-dose Alpinia officinarum Hance group, the high and low dose groups of Alpinia galanga （L.） Willd. and seeds of Alpinia galanga （L.） Willd. showed a significant or extremely signficant increase （P<0.01 or P<0.05）. Three alpinia herbs flavonoids can promote gastric mucosal repair in rats with gastric ulcer cold syndrome. The action mechanism is related with reducing MDA content, increasing SOD enzyme activity, and enhancing the content of bFGF and PDGF content. It is speculated that flavonoids play a role in gastric mucosa repair by promoting gastric mucosa antioxidant capacity, reducing the gastric mucous membrane peroxidation damage, promoting the epithelial cell proliferation of injury, and repairing damaged tissue.

Key words: alpinia herbs, flavonoids, gastric ulcer cold syndrome, mechanism of action

CLC Number:

QIN Hua-zhen, ZHONG Gui, CHEN Jun-qi, HE Rui-kun, DAI Qing-ling, LIU Jun-hui. Study on the mechanism of flavonoids from three kinds of alpinia herbs in rats with gastric ulcer cold syndrome[J]. HUBEI AGRICULTURAL SCIENCES, 2022, 61(15): 153-156.

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