HUBEI AGRICULTURAL SCIENCES ›› 2018, Vol. 57 ›› Issue (10): 95-97.doi: 10.14088/j.cnki.issn0439-8114.2018.10.024

• Animal Husbandry & Veterinary Medicine • Previous Articles     Next Articles

Study on in Vitro Release of Eprinomectin in Situ Gel Injection

ZHANG Zhen-dong, LIU Xi-wang, MA Ning, SHEN Dong-shuai, LI Jian-yong   

  1. Lanzhou Institute of Husbandry, Pharmaceutical Science of CAAS/Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture/Key Lab of New Animal Drug Project of Gansu Province, Lanzhou730050, China
  • Received:2018-01-16 Online:2018-05-25 Published:2019-12-19

Abstract: The purpose of this study was to determine the release of in situ gel injection of Eprinomectin in vitro (EPR). The vitro release of EPR in situ gel injection was measured by high performance liquid chromatography(HPLC) using PBS buffer as a release medium. The results showed that it is feasible to determine the vitro release of EPR in situ gel injection by HPLC and the vitro release curve showed that EPR in situ gel injection had the characteristics of sustained release. This conclusion was that the HPLC method was suitable for the vitro release of EPR in situ gel injection with pH 7.4 PBS buffer solution as a release medium.

Key words: eprinomectin, HPLC, in situ gel injections, vitro release

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