[1] SAUNIER B,KILKER R J,TKACZ J S,et al.Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin,an inhibitor of processing glucosidases[J].J Biol Chem,1982,257(23):14155-14161. [2] GROSS V,ANDUS T,TRAN-THI T A,et al. 1-deoxynojirimycin impairs oligosaccharide processing of alpha 1-proteinase inhibitor and inhibits its secretion in primary cultures of rat hepatocytes[J].J Biol Chem,1983,258(20):12203-12209. [3] LI Y G,JI D F,ZHONG S,et al.1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice[J].Sci Rep,2013,3:1377. [4] HU X Q,THAKUR K,CHEN G H,et al.Metabolic effect of 1-deoxynojirimycin from mulberry leaves on db/db diabetic mice using liquid chromatography-mass spectrometry based metabolomics[J].J Agric Food Chem,2017,65(23):4658-4667. [5] SEVSEK A,CELAN M,ERJAVEC B,et al.Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of beta-glucocerebrosidase[J].Org Biomol Chem,2016,14(37):8670-8673. [6] KWON H J,CHUNG J Y,KIM J Y,et al.Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects:in vivo and in vitro studies[J].J Agric Food Chem,2011,59(7):3014-3019. [7] LI Y G,JI D F,ZHONG S,et al.Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase,phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice[J]. J Ethnopharmacol,2011,134(3):961-970. [8] KOJIMA Y,KIMURA T,NAKAGAWA K,et al.Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans[J].J Clin Biochem Nutr,2010,47(2):155-161. [9] LIU Q,LI X,LI C,et al.1-deoxynojirimycin alleviates liver injury and improves hepatic glucose metabolism in db/db mice[J].Molecules,2016,21(3):279. [10] DO H J,CHUNG J H,HWANG J W,et al.1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice[J].Food Chem Toxicol,2015,75:1-7. [11] LIU Q,LI X,LI C,et al.1-deoxynojirimycin alleviates insulin resistance via activation of insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[J].Molecules,2015, 20(12):21700-21714. [12] KIJIMA R E S,HONMA T,YAMAMOTO K,et al. 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells[J].Exp Gerontol,2014,55(5):63-69. [13] CHAN K C,LIN M C,HUANG C N,et al.Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK[J].J Agric Food Chem,2013,61(41):9867-9875. [14] TSUDUKI T,KIKUCHI I,KIMURA T,et al.Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice[J]. Food Chem,2013,139(1-4):16-23. [15] KONG W H,OH S H,AHN Y R,et al.Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models[J].J Agric Food Chem,2008,56(8):2613-2619. [16] LIU M,WANG S,ZHOU Y D,et al.An iminosugar N-pentafluorobenzyl-1-deoxynojirimycin as a novel potential immunosuppressant for the treatment of Th2-related diseases[J].Bioorg Med Chem Lett,2012,22(1):564-570. [17] 彭忠田,申璀,谭德明,等.脱氧野尻霉素衍生物抗乙型肝炎病毒的体外试验研究[J].中国药房,2007(1):22-24. |