Abstract: Thin layer chromatography was used to identify ginseng and safflower as control materials. The content of fumarate in the preparation was determined by high performance liquid chromatography,to establish the quality standard of Shenhong Quyu Sanjie granules. The results showed that the thin-layer atlases of the ginseng control medicine and the safflower control medicine showed clear spots, good separation effect, strong specificity, and no interference in the limit control. It has a good linear relationship with the peak area in 7.174~35.940 μg/mL（r=0.999 89）. The average sample recovery was good. The method is simple, accurate and reproducible, and can be used for the quality control method of Shenhong Quyu Sanjie granules.

Key words: Shenhong Quyu Sanjie granules, yanhusuosutin, thin layer chromatography, high performance liquid chromatography